Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 18/20 | 0.66 |
| ▸ | RARG | P13631 | 17/20 | 0.66 |
| ▸ | RARA | P10276 | 13/20 | 0.66 |
| ▸ | RXRA | P19793 | 12/20 | 0.66 |
| ▸ | RXRB | P28702 | 4/20 | 0.66 |
| ▸ | RXRG | P48443 | 4/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.50 |
| ▸ | GMNN | O75496 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9078166 | 1.00 | RARB (0.66) | RARBRARGRARARXRARXRB | |
| SCHEMBL7217799 | 1.00 | RARB (0.66) | RARBRARGRARARXRARXRB | |
| SCHEMBL7218168 | 0.86 | RARB (0.49) | RARBRARGRARARXRARXRB | |
| SCHEMBL7218170 | 0.86 | RARB (0.49) | RARBRARGRARARXRARXRB | |
| SCHEMBL9076001 | 0.85 | RARB (0.71) | RARBRARGRARARXRARXRB | |
| SCHEMBL9076004 | 0.85 | RARB (0.71) | RARBRARGRARARXRARXRB | |
| SCHEMBL9076000 | 0.85 | RARB (0.71) | RARBRARGRARARXRARXRB | |
| SCHEMBL10845294 | 0.85 | RARB (0.85) | RARBRARGRARARXRARXRB | |
| SCHEMBL10845299 | 0.85 | RARB (0.85) | RARBRARGRARARXRARXRB | |
| SCHEMBL8462110 | 0.80 | RXRA (0.41) | RARBRARGRARARXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6624188-B1 | Administered to treat or prevent one or more of the diseases and conditions selected from the group consisting of dermatoses, atherosclerosis and restenosis resulting from neointimal hyperproliferation, non-malignant and | ALLERGAN, INC. | 2003-09-23 | — | — | US | disclosed |
| US-5556996-A | Oxiranyls disubstituted with a phenyl group and a substituted chromanyl or tetrahydroquinolinyl group having retinoid like activity | ALLERGAN (US) | 1996-09-17 | — | — | US | disclosed |
| US-5324840-A | Skin disorders | ALLERGAN, INC. (US) | 1994-06-28 | — | — | US | disclosed |