Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 7/20 | 0.47 |
| ▸ | CA1 | P00915 | 7/20 | 0.47 |
| ▸ | CA2 | P00918 | 7/20 | 0.47 |
| ▸ | CA9 | Q16790 | 7/20 | 0.47 |
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | SUCNR1 | Q9BXA5 | 7/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7216150 | 0.99 | CA12 (0.48) | CA12CA1CA2CA9BRD4 | |
| SCHEMBL7215916 | 0.97 | CA12 (0.47) | CA12CA1CA2CA9BRD4 | |
| SCHEMBL7216544 | 0.86 | CA12 (0.50) | CA12CA1CA2CA9BRD4 | |
| SCHEMBL7217838 | 0.83 | CA12 (0.49) | CA12CA1CA2CA9BRD4 | |
| SCHEMBL7216596 | 0.80 | CA12 (0.48) | CA12CA1CA2CA9SUCNR1 | |
| SCHEMBL7215536 | 0.79 | ITGB3 (0.44) | CA12CA1CA2CA9SUCNR1 | |
| SCHEMBL7215543 | 0.79 | ITGB3 (0.44) | CA12CA1CA2CA9SUCNR1 | |
| SCHEMBL7217925 | 0.79 | ITGB3 (0.45) | CA12CA1CA2CA9SUCNR1 | |
| SCHEMBL7217933 | 0.79 | ITGB3 (0.45) | CA12CA1CA2CA9SUCNR1 | |
| SCHEMBL7215547 | 0.77 | CA12 (0.49) | CA12CA1CA2CA9BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6630488-B1 | Quinolizinones as integrin inhibitors | BIOCHEM PHARMA, INC. (CA) | 2003-10-07 | — | — | US | disclosed |
| EP-1115724-A1 | QUINOLIZINONES AS INTEGRIN INHIBITORS | Shire Biochem Inc. (CA) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000017197-A1 | QUINOLIZINONES AS INTEGRIN INHIBITORS | BIOCHEM PHARMA INC. (US) | 2000-03-30 | — | — | WO | disclosed |