Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 2/20 | 0.45 |
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30969232 | 0.93 | MAOB (0.49) | MAOBHRH3BCHEACHE | |
| SCHEMBL6309786 | 0.82 | L3MBTL1 (0.45) | KDM4E | |
| SCHEMBL3184436 | 0.79 | KMT2A (0.44) | HRH3 | |
| SCHEMBL6302880 | 0.79 | PARP10 (0.58) | KDM4E | |
| SCHEMBL29889518 | 0.78 | CHEK2 (0.48) | — | |
| SCHEMBL2234368 | 0.78 | KDM4E (0.53) | MAOBHRH3KDM4E | |
| SCHEMBL11416870 | 0.78 | KMT2A (0.42) | KDM4E | |
| SCHEMBL20576023 | 0.77 | HRH3 (0.46) | MAOBHRH3KDM4EBCHEACHE | |
| SCHEMBL26028754 | 0.75 | MAPK1 (0.53) | — | |
| SCHEMBL6304823 | 0.75 | CHEK1 (0.42) | MAOBHRH3KDM4EBCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6653471-B2 | Tricyclic heteroaromatic compounds containing pyrrole ring; central nervous system disorder treatment; side effect reduction | NEUROGEN CORPORATION | 2003-11-25 | — | — | US | disclosed |