Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.35 |
| ▸ | THRB | P10828 | 3/20 | 0.34 |
| ▸ | THRA | P10827 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.32 |
| ▸ | LSS | P48449 | 9/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7218350 | 0.85 | LSS (0.43) | LSS | |
| SCHEMBL7212204 | 0.84 | LSS (0.39) | LSS | |
| SCHEMBL7217096 | 0.83 | HDAC3 (0.35) | HSD17B10LSS | |
| SCHEMBL7218354 | 0.82 | HDAC8 (0.35) | SPHK1THRBTHRALSS | |
| SCHEMBL7218503 | 0.81 | LSS (0.45) | THRBTHRALSS | |
| SCHEMBL7218476 | 0.80 | LSS (0.41) | LSS | |
| SCHEMBL6988448 | 0.80 | LSS (0.35) | LSS | |
| SCHEMBL7218498 | 0.80 | LSS (0.47) | LSS | |
| SCHEMBL7212171 | 0.80 | LSS (0.47) | LSS | |
| SCHEMBL7212197 | 0.78 | LSS (0.36) | LSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358162-A1 | DIHYDROINDOLE AND TETRAHYDROQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002050041-A1 | DIHYDROINDOLE AND TETRAHYDROQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-27 | — | — | WO | disclosed |