Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 14/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.35 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7212171 | 0.91 | LSS (0.47) | LSS | |
| SCHEMBL7218476 | 0.91 | LSS (0.41) | LSS | |
| SCHEMBL7218498 | 0.91 | LSS (0.47) | LSS | |
| SCHEMBL7212204 | 0.90 | LSS (0.39) | LSS | |
| SCHEMBL7213268 | 0.85 | LSS (0.35) | LSS | |
| SCHEMBL7217117 | 0.84 | LSS (0.58) | LSS | |
| SCHEMBL6988448 | 0.83 | LSS (0.35) | LSS | |
| SCHEMBL7217096 | 0.81 | HDAC3 (0.35) | LSSSIGMAR1 | |
| SCHEMBL7218357 | 0.81 | SPHK1 (0.35) | LSSTHRATHRB | |
| SCHEMBL7218501 | 0.81 | LSS (0.45) | LSSSIGMAR1THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358162-A1 | DIHYDROINDOLE AND TETRAHYDROQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002050041-A1 | DIHYDROINDOLE AND TETRAHYDROQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-27 | — | — | WO | disclosed |