Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.44 |
| ▸ | THRA | P10827 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL565857 | 0.92 | DRD2 (0.45) | DRD2DRD4SLC6A2HTR2AHTR2C | |
| SCHEMBL27610237 | 0.90 | DRD2 (0.46) | THRBDRD2DRD4SLC6A2HTR2A | |
| SCHEMBL11524478 | 0.86 | DRD2 (0.47) | THRBDRD2DRD4HTR2AHTR2C | |
| SCHEMBL5639446 | 0.84 | DRD2 (0.36) | SIGMAR1DRD2DRD4 | |
| SCHEMBL20846119 | 0.80 | SMN1; SMN2 (0.43) | DRD2SLC6A2HTR2AHTR2CSLC6A4 | |
| SCHEMBL8529985 | 0.80 | DRD2 (0.50) | THRBDRD2DRD4HTR2AHTR2C | |
| SCHEMBL27610259 | 0.79 | SMN1; SMN2 (0.44) | DRD2SLC6A2HTR2AHTR2CSLC6A4 | |
| SCHEMBL27091898 | 0.78 | SLC6A2 (0.46) | DRD2SLC6A2HTR2AHTR2CSLC6A4 | |
| SCHEMBL5535606 | 0.77 | DRD2 (0.45) | THRBDRD2DRD4HTR2AHTR2C | |
| SCHEMBL5638061 | 0.77 | KDM4E (0.41) | SIGMAR1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358162-A1 | DIHYDROINDOLE AND TETRAHYDROQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002050041-A1 | DIHYDROINDOLE AND TETRAHYDROQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-27 | — | — | WO | disclosed |