Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.58 |
| ▸ | CYP26A1 | O43174 | 4/20 | 0.58 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.58 |
| ▸ | RXRA | P19793 | 13/20 | 0.56 |
| ▸ | RXRB | P28702 | 10/20 | 0.56 |
| ▸ | RARB | P10826 | 10/20 | 0.56 |
| ▸ | RARG | P13631 | 9/20 | 0.56 |
| ▸ | RXRG | P48443 | 7/20 | 0.56 |
| ▸ | RARA | P10276 | 8/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | GMNN | O75496 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5367554 | 0.91 | CYP3A4 (0.56) | CYP3A4CYP26A1CYP26B1RXRARXRB | |
| SCHEMBL7143184 | 0.89 | CYP3A4 (0.54) | CYP3A4CYP26A1CYP26B1RXRARXRB | |
| SCHEMBL2195789 | 0.87 | CYP3A4 (0.61) | CYP3A4CYP26A1CYP26B1RXRARXRB | |
| SCHEMBL9184959 | 0.86 | CYP3A4 (0.57) | CYP3A4CYP26A1CYP26B1RXRARXRB | |
| SCHEMBL9588198 | 0.86 | CYP26A1 (0.60) | CYP3A4CYP26A1CYP26B1RXRARXRB | |
| SCHEMBL19072651 | 0.85 | CYP3A4 (0.63) | CYP3A4CYP26A1CYP26B1RXRARXRB | |
| SCHEMBL9587288 | 0.84 | CYP3A4 (0.56) | CYP3A4CYP26A1CYP26B1RXRARXRB | |
| SCHEMBL9588044 | 0.84 | CYP26A1 (0.59) | CYP3A4CYP26A1CYP26B1RXRARXRB | |
| SCHEMBL9587941 | 0.83 | CYP3A4 (0.54) | CYP3A4CYP26A1CYP26B1RXRARXRB | |
| SCHEMBL8807415 | 0.83 | CYP26B1 (0.58) | CYP3A4CYP26A1CYP26B1RXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6624188-B1 | Administered to treat or prevent one or more of the diseases and conditions selected from the group consisting of dermatoses, atherosclerosis and restenosis resulting from neointimal hyperproliferation, non-malignant and | ALLERGAN, INC. | 2003-09-23 | — | — | US | disclosed |
| US-5324840-A | Skin disorders | ALLERGAN, INC. (US) | 1994-06-28 | — | — | US | disclosed |