Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.56 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.56 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.56 |
| ▸ | RXRA | P19793 | 10/20 | 0.54 |
| ▸ | RXRB | P28702 | 9/20 | 0.54 |
| ▸ | RXRG | P48443 | 6/20 | 0.54 |
| ▸ | RARB | P10826 | 6/20 | 0.54 |
| ▸ | RARG | P13631 | 5/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.52 |
| ▸ | RARA | P10276 | 4/20 | 0.51 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7143184 | 0.95 | CYP3A4 (0.54) | CYP3A4CYP26A1CYP26B1RXRARXRB | |
| SCHEMBL7218543 | 0.91 | CYP3A4 (0.58) | CYP3A4CYP26A1CYP26B1RXRARXRB | |
| SCHEMBL8807415 | 0.87 | CYP26B1 (0.58) | CYP3A4CYP26A1CYP26B1RXRARXRB | |
| SCHEMBL2195789 | 0.84 | CYP3A4 (0.61) | CYP3A4CYP26A1CYP26B1RXRARXRB | |
| SCHEMBL9184959 | 0.83 | CYP3A4 (0.57) | CYP3A4CYP26A1CYP26B1RXRARXRB | |
| SCHEMBL9588198 | 0.83 | CYP26A1 (0.60) | CYP3A4CYP26A1CYP26B1RXRARXRB | |
| SCHEMBL19072651 | 0.82 | CYP3A4 (0.63) | CYP3A4CYP26A1CYP26B1RXRARXRB | |
| SCHEMBL9588044 | 0.82 | CYP26A1 (0.59) | CYP3A4CYP26A1CYP26B1RXRARXRB | |
| SCHEMBL9587288 | 0.82 | CYP3A4 (0.56) | CYP3A4CYP26A1CYP26B1RXRARXRB | |
| SCHEMBL9587941 | 0.81 | CYP3A4 (0.54) | CYP3A4CYP26A1CYP26B1RXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070099991-A1 | SELECTIVE RXR LIGANDS | HAFFNER CURT D | 2007-05-03 | — | — | US | disclosed |
| US-7173134-B2 | Selective RXR ligands | SMITHKLINE BEECHAM CORPORATION (US) | 2007-02-06 | — | — | US | disclosed |
| US-20040198980-A1 | Selective rxr ligands | SMITHKLINE BEECHAM CORPORATION | 2004-10-07 | — | — | US | disclosed |
| EP-1430042-A2 | BICYCLIC HETEROCYCLES AS RXR LIGANDS | SmithKline Beecham Corporation (US) | 2004-06-23 | — | — | EP | disclosed |
| WO-2003027090-A2 | BICYCLIC HETEROCYCLES AS RXR LIGANDS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |
| US-6403810-B2 | RESPIRATORY SYSTEM DISORDERS | HOFFMANN-LA ROCHE INC. | 2002-06-11 | — | — | US | disclosed |
| US-20020019438-A1 | Thiophene derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2002-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040198980-A1 | Selective rxr ligands | RXRA, RXRB, RXRG | CYP3A4 968/4885CYP26A1 315/4885CYP26B1 268/4885 |
| US-20020019438-A1 | Thiophene derivatives | RARG, RARA, RARB | CYP3A4 877/4885CYP26A1 232/4885CYP26B1 337/4885 |
| US-20070099991-A1 | SELECTIVE RXR LIGANDS | RXRB, RXRA, RXRG | CYP3A4 901/4885CYP26A1 374/4885CYP26B1 285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.