Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 3/20 | 0.57 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.57 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7678316 | 0.88 | TDP1 (0.46) | CYP4F2CYP4A11CYP4Z1TDP1PDE3B | |
| SCHEMBL7680938 | 0.85 | DGKA (0.46) | CYP4F2CYP4A11TDP1APPGAA | |
| SCHEMBL7219961 | 0.84 | TSHR (0.43) | CYP4F2CYP4A11PDE3BPDE3AMAPT | |
| SCHEMBL29024345 | 0.81 | CYP4F2 (0.61) | CYP4F2CYP4A11CYP4Z1TDP1PDE3B | |
| SCHEMBL7219224 | 0.81 | SMN1; SMN2 (0.44) | CYP4F2CYP4A11CYP4Z1MAPTMGAM | |
| SCHEMBL63490 | 0.81 | CYP4F2 (0.56) | CYP4F2CYP4A11CYP4Z1TDP1MAPT | |
| SCHEMBL13412641 | 0.80 | CYP4F2 (0.59) | CYP4F2CYP4A11CYP4Z1TDP1PDE3B | |
| SCHEMBL490704 | 0.80 | CYP4F2 (0.59) | CYP4F2CYP4A11CYP4Z1TDP1PDE3B | |
| SCHEMBL7226304 | 0.79 | TSHR (0.41) | CYP4F2CYP4A11TDP1MAPT | |
| SCHEMBL7687115 | 0.79 | HDAC8 (0.36) | CYP4F2CYP4A11TDP1HRH3APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6337423-B1 | BIND TO VOLTAGE-GATED SODIUM ION CHANNELS TO MODULATE ACTIVITY | ADVANCED MEDICINE, INC. | 2002-01-08 | — | — | US | claimed |
| US-6576791-B1 | Local anesthetic compounds and uses | THERAVANCE, INC. | 2003-06-10 | — | — | US | disclosed |
| US-6495681-B1 | PRODUCING LOCAL ANESTHESIA OF LONG-DURATION. THE COMPOUNDS OF THIS INVENTION ARE MULTIBINDING COMPOUNDS THAT COMPRISE FROM 2 TO 10 LIGANDS COVALENTLY ATTACHED TO A LINKER OR LINKERS, EACH LIGAND BEING CAPABLE OF BINDING TO A LIGAND BINDING SITE | THERAVANCE INC. | 2002-12-17 | — | — | US | disclosed |
| US-6337423-B1 | BIND TO VOLTAGE-GATED SODIUM ION CHANNELS TO MODULATE ACTIVITY | ADVANCED MEDICINE, INC. | 2002-01-08 | — | — | US | disclosed |
| CN-1295558-A | Novel local anesthetic compounds and uses | ADVANCED MEDICINE INC (US) | 2001-05-16 | — | — | CN | disclosed |