Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 11/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MARK4 | Q96L34 | 1/20 | 0.32 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7219642 | 1.00 | F2 (0.37) | F2LMNASMN1; SMN2HTTMETAP2 | |
| SCHEMBL7219640 | 1.00 | F2 (0.37) | F2LMNASMN1; SMN2HTTMETAP2 | |
| SCHEMBL7446869 | 0.82 | EZH2 (0.35) | F2LMNAMETAP2MEN1KMT2A | |
| SCHEMBL7214972 | 0.75 | KDM4E (0.40) | — | |
| SCHEMBL7214969 | 0.75 | KDM4E (0.40) | — | |
| SCHEMBL7214985 | 0.75 | KDM4E (0.40) | — | |
| SCHEMBL7216088 | 0.71 | KDM4E (0.43) | SMN1; SMN2POLBTSHRMEN1KMT2A | |
| SCHEMBL7216094 | 0.71 | KDM4E (0.43) | SMN1; SMN2POLBTSHRMEN1KMT2A | |
| SCHEMBL7216082 | 0.71 | KDM4E (0.43) | SMN1; SMN2POLBTSHRMEN1KMT2A | |
| SCHEMBL23461191 | 0.61 | F2 (0.73) | F2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610692-B1 | Anticoagulants | MERCK & CO., INC. | 2003-08-26 | — | — | US | disclosed |
| EP-1124822-A4 | THROMBIN INHIBITORS | MERCK & CO INC (US) | 2002-04-03 | — | — | EP | disclosed |
| EP-1124822-A1 | THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 2001-08-22 | — | — | EP | disclosed |
| WO-2000026211-A1 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2000-05-11 | — | — | WO | disclosed |