Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 3/20 | 1.00 |
| ▸ | APP | P05067 | 11/20 | 0.78 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.78 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.78 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.78 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.78 |
| ▸ | MAPT | P10636 | 3/20 | 0.78 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.78 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.78 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.78 |
| ▸ | STAT3 | P40763 | 2/20 | 0.78 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.78 |
| ▸ | RELA | Q04206 | 2/20 | 0.78 |
| ▸ | CAMK2A | Q9UQM7 | 2/20 | 0.78 |
| ▸ | KDR | P35968 | 1/20 | 0.78 |
| ▸ | TTR | P02766 | 1/20 | 0.57 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.56 |
| ▸ | TYR | P14679 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7874021 | 1.00 | MMP9 (1.00) | MMP9APPPTGS2PRKCEPRKCQ | |
| SCHEMBL9553254 | 0.89 | MMP9 (0.80) | MMP9APPPTGS2PRKCEPRKCQ | |
| Curcumin Pyrazole SCHEMBL9553585 | 0.87 | APP (1.00) | MMP9APPPTGS2PRKCEPRKCQ | |
| Curcumin Pyrazole SCHEMBL13907614 | 0.87 | APP (1.00) | MMP9APPPTGS2PRKCEPRKCQ | |
| Curcumin Pyrazole SCHEMBL29798918 | 0.87 | APP (1.00) | MMP9APPPTGS2PRKCEPRKCQ | |
| SCHEMBL6846511 | 0.85 | MMP9 (0.74) | MMP9APPPTGS2PRKCEPRKCQ | |
| SCHEMBL9553564 | 0.85 | MMP9 (0.74) | MMP9APPPTGS2PRKCEPRKCQ | |
| SCHEMBL6846508 | 0.85 | MMP9 (0.74) | MMP9APPPTGS2PRKCEPRKCQ | |
| SCHEMBL6841454 | 0.84 | MMP9 (0.73) | MMP9APPPTGS2PRKCEPRKCQ | |
| SCHEMBL6841452 | 0.84 | MMP9 (0.73) | MMP9APPPTGS2PRKCEPRKCQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0332147-B1 | COMPOSITIONS WITH ENHANCED PENETRATION | WARNER-LAMBERT COMPANY (US) | 1993-06-16 | — | — | EP | claimed |
| US-5019395-A | Transdermal drug delivery | WARNER-LAMBERT COMPANY (US) | 1991-05-28 | — | — | US | claimed |
| EP-0245825-B1 | STYRYL PYRAZOLES, ISOXAZOLES AND ANALOGS THEREOF HAVING ACTIVITY AS 5-LIPOXY-GENASE INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | WARNER-LAMBERT COMPANY (US) | 1991-03-13 | — | — | EP | claimed |
| US-4924002-A | REACTION WITH MOLYBDENUM CARBONYL AND HYDRAZINE | WARNER-LAMBERT COMPANY (US) | 1990-05-08 | — | — | US | claimed |
| EP-0332147-A2 | Compositions with enhanced penetration | WARNER-LAMBERT COMPANY (US) | 1989-09-13 | — | — | EP | claimed |
| EP-0245825-A1 | Styryl pyrazoles, isoxazoles and analogs thereof having activity as 5-lipoxy-genase inhibitors and pharmaceutical compositions containing them | WARNER-LAMBERT COMPANY (US) | 1987-11-19 | — | — | EP | claimed |
| US-6627652-B1 | Treatment of diseases or conditions of the type which are normally treated with retinoid-like compounds is disclosed, with pharmaceutical compositions containing an active compound which is a selective agonist of the RXR retinoid | ALLERGAN, INC. | 2003-09-30 | — | — | US | disclosed |
| US-6624188-B1 | Administered to treat or prevent one or more of the diseases and conditions selected from the group consisting of dermatoses, atherosclerosis and restenosis resulting from neointimal hyperproliferation, non-malignant and | ALLERGAN, INC. | 2003-09-23 | — | — | US | disclosed |
| EP-0848611-B1 | TACRINE PATCH | HEXAL AG (DE) | 2001-07-18 | — | — | EP | disclosed |
| EP-0848611-A2 | TACRINE PATCH | HEXAL AG (DE) | 1998-06-24 | — | — | EP | disclosed |
| WO-1997009050-A2 | TACRINE PATCH | HEXAL AG (DE) | 1997-03-13 | — | — | WO | disclosed |
| US-5455265-A | For mammals; skin disorders, cancer, inflammatory disease, cardiovascular diorders, autoimmune diseases and others | ALLERGAN, INC. (US) | 1995-10-03 | — | — | US | disclosed |
| US-5324840-A | Skin disorders | ALLERGAN, INC. (US) | 1994-06-28 | — | — | US | disclosed |
| US-5208251-A | Compounds for antiinflammatory agents, antiallergens, antiarthritic, antiulcer agents | WARNER-LAMBERT COMPANY (US) | 1993-05-04 | — | — | US | disclosed |
| US-5019395-A | Transdermal drug delivery | WARNER-LAMBERT COMPANY (US) | 1991-05-28 | — | — | US | disclosed |
| EP-0245825-B1 | STYRYL PYRAZOLES, ISOXAZOLES AND ANALOGS THEREOF HAVING ACTIVITY AS 5-LIPOXY-GENASE INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | WARNER-LAMBERT COMPANY (US) | 1991-03-13 | — | — | EP | disclosed |
| US-4924002-A | REACTION WITH MOLYBDENUM CARBONYL AND HYDRAZINE | WARNER-LAMBERT COMPANY (US) | 1990-05-08 | — | — | US | disclosed |
| US-4877881-A | SUNSCREEN | WARNER-LAMBERT COMPANY (US) | 1989-10-31 | — | — | US | disclosed |
| EP-0332147-A2 | Compositions with enhanced penetration | WARNER-LAMBERT COMPANY (US) | 1989-09-13 | — | — | EP | disclosed |
| EP-0245825-A1 | Styryl pyrazoles, isoxazoles and analogs thereof having activity as 5-lipoxy-genase inhibitors and pharmaceutical compositions containing them | WARNER-LAMBERT COMPANY (US) | 1987-11-19 | — | — | EP | disclosed |