Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.61 |
| ▸ | ERBB2 | P04626 | 12/20 | 0.61 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.59 |
| ▸ | JAK3 | P52333 | 1/20 | 0.57 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.56 |
| ▸ | DUS2 | Q9NX74 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7221059 | 0.96 | EGFR (0.62) | EGFRERBB2ERBB4JAK3KDR | |
| SCHEMBL4201064 | 0.90 | EGFR (0.72) | EGFRERBB2ERBB4 | |
| SCHEMBL4187462 | 0.89 | EGFR (0.75) | EGFRERBB2ERBB4JAK3 | |
| SCHEMBL7216169 | 0.84 | EGFR (0.63) | EGFRERBB2ERBB4JAK3ERBB3 | |
| SCHEMBL1418437 | 0.80 | EGFR (0.64) | EGFRERBB2ERBB4JAK3 | |
| SCHEMBL1418438 | 0.80 | EGFR (0.64) | EGFRERBB2ERBB4JAK3 | |
| SCHEMBL1418004 | 0.80 | EGFR (0.65) | EGFRERBB2ERBB4JAK3ERBB3 | |
| SCHEMBL1418007 | 0.80 | EGFR (0.65) | EGFRERBB2ERBB4JAK3ERBB3 | |
| SCHEMBL21251171 | 0.79 | EGFR (0.76) | EGFRERBB2ERBB4JAK3ERBB3 | |
| SCHEMBL13083349 | 0.79 | EGFR (0.76) | EGFRERBB2ERBB4JAK3ERBB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6602863-B1 | Irreversible inhibitors of tyrosine kinases | WARNER-LAMBERT COMPANY | 2003-08-05 | — | — | US | disclosed |