Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.63 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.63 |
| ▸ | DUS2 | Q9NX74 | 1/20 | 0.63 |
| ▸ | ERBB2 | P04626 | 9/20 | 0.61 |
| ▸ | ERBB4 | Q15303 | 4/20 | 0.59 |
| ▸ | JAK3 | P52333 | 2/20 | 0.59 |
| ▸ | GAK | O14976 | 2/20 | 0.57 |
| ▸ | LCK | P06239 | 2/20 | 0.57 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.57 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.57 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.57 |
| ▸ | SRC | P12931 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 1/20 | 0.57 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.57 |
| ▸ | MC3R | P41968 | 1/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7219678 | 0.95 | EGFR (0.64) | EGFRERBB3DUS2ERBB2ERBB4 | |
| SCHEMBL7220061 | 0.86 | EGFR (0.79) | EGFRERBB2ERBB4JAK3 | |
| SCHEMBL1418417 | 0.85 | EGFR (0.74) | EGFRERBB3DUS2ERBB2ERBB4 | |
| SCHEMBL1418419 | 0.85 | EGFR (0.74) | EGFRERBB3DUS2ERBB2ERBB4 | |
| SCHEMBL7219974 | 0.84 | EGFR (0.61) | EGFRERBB3DUS2ERBB2ERBB4 | |
| SCHEMBL7802553 | 0.83 | EGFR (0.67) | EGFRERBB3DUS2ERBB2ERBB4 | |
| SCHEMBL7807734 | 0.81 | EGFR (0.65) | EGFRERBB3DUS2ERBB2ERBB4 | |
| SCHEMBL29731552 | 0.81 | EGFR (0.82) | EGFRERBB3DUS2ERBB2ERBB4 | |
| SCHEMBL22847994 | 0.81 | EGFR (0.82) | EGFRERBB3DUS2ERBB2ERBB4 | |
| SCHEMBL19027164 | 0.81 | EGFR (0.61) | EGFRERBB3DUS2ERBB2ERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6602863-B1 | Irreversible inhibitors of tyrosine kinases | WARNER-LAMBERT COMPANY | 2003-08-05 | — | — | US | disclosed |