Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 16/20 | 0.54 |
| ▸ | CHRNB2 | P17787 | 6/20 | 0.54 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | HTR3E | A5X5Y0 | 5/20 | 0.44 |
| ▸ | HTR3B | O95264 | 5/20 | 0.44 |
| ▸ | HTR3A | P46098 | 5/20 | 0.44 |
| ▸ | HTR3D | Q70Z44 | 5/20 | 0.44 |
| ▸ | HTR3C | Q8WXA8 | 5/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7061274 | 1.00 | CHRNA7 (0.54) | CHRNA7CHRNB2CHRNA4NPC1RAB9A | |
| SCHEMBL7225655 | 0.93 | CHRNB2 (0.58) | CHRNA7CHRNB2CHRNA4NPC1RAB9A | |
| SCHEMBL7064251 | 0.88 | CHRNA7 (0.47) | CHRNA7CHRNB2CHRNA4HTR3EHTR3B | |
| SCHEMBL7059301 | 0.87 | CHRNA7 (0.45) | CHRNA7CHRNB2CHRNA4HTR3EHTR3B | |
| SCHEMBL7064296 | 0.87 | CHRNA7 (0.47) | CHRNA7CHRNB2CHRNA4NPC1RAB9A | |
| SCHEMBL7064093 | 0.86 | CHRNA7 (0.50) | CHRNA7CHRNB2CHRNA4HTR3EHTR3B | |
| SCHEMBL7060462 | 0.85 | CHRNA7 (0.51) | CHRNA7CHRNB2CHRNA4HTR3EHTR3B | |
| SCHEMBL7125473 | 0.85 | CHRNA7 (0.44) | CHRNA7CHRNB2CHRNA4NPC1RAB9A | |
| SCHEMBL7062719 | 0.85 | CHRNA7 (0.45) | CHRNA7CHRNB2CHRNA4HTR3EHTR3B | |
| SCHEMBL7064071 | 0.85 | CHRNA7 (0.56) | CHRNA7CHRNB2CHRNA4HTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6599916-B2 | Treating a disease or condition in a mammal, wherein the alpha 7 nicotinic acetylcholine receptor is implicated, Alzheimer's disease, pre-senile dementia (mild cognitive impairment), or senile dementia. | PHARMACIA & UPJOHN COMPANY | 2003-07-29 | — | — | US | disclosed |