Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 15/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 15/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4196221 | 0.76 | CYP19A1 (0.55) | CYP11B1CYP11B2CYP3A4CYP19A1 | |
| SCHEMBL5998609 | 0.76 | CYP19A1 (0.43) | CYP11B1CYP11B2CYP3A4CYP19A1 | |
| Hydrochloric Acid SCHEMBL20186907 | 0.74 | CYP19A1 (0.53) | CYP11B1CYP11B2CYP3A4CYP19A1 | |
| SCHEMBL7222091 | 0.74 | FNTA (0.47) | CYP11B1CYP11B2 | |
| Hydrochloric Acid SCHEMBL7220637 | 0.73 | FNTA (0.47) | CYP11B1CYP11B2 | |
| SCHEMBL7221516 | 0.73 | CYP11B1 (0.37) | CYP11B1CYP11B2CYP3A4CYP3A5SLC22A12 | |
| SCHEMBL6000406 | 0.72 | CYP19A1 (0.53) | CYP3A4CYP3A5CYP19A1 | |
| SCHEMBL5999494 | 0.71 | CYP19A1 (0.50) | CYP11B1CYP11B2CYP3A4CYP19A1 | |
| SCHEMBL495417 | 0.71 | TRPV4 (0.52) | CYP11B1CYP11B2 | |
| SCHEMBL5998626 | 0.70 | CYP19A1 (0.54) | CYP11B1CYP11B2CYP3A4CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6525074-B2 | Peptidomimetic macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras | MERCK & CO., INC. | 2003-02-25 | — | — | US | disclosed |
| US-20020049217-A1 | Inhibitors of prenyl-protein transferase | MERCK SHARP & DOHME CORP. | 2002-04-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020049217-A1 | Inhibitors of prenyl-protein transferase | FNTA, KRAS, NRAS | CYP11B1 2070/4885CYP11B2 2682/4885CYP3A4 2657/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.