Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.61 |
| ▸ | NPC1 | O15118 | 8/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 3,5-Diphenylisoxazole SCHEMBL1421260 | 0.76 | NPC1 (1.00) | RAB9ANPC1ALDH1A1NOTUMSMN1; SMN2 | |
| SCHEMBL23221303 | 0.75 | RAB9A (0.57) | RAB9ANPC1ALDH1A1NOTUMSMN1; SMN2 | |
| SCHEMBL28670403 | 0.75 | RAB9A (1.00) | RAB9ANPC1SMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL10341983 | 0.74 | RAB9A (0.67) | RAB9ANPC1ALDH1A1NOTUMSMN1; SMN2 | |
| SCHEMBL8258186 | 0.74 | NPC1 (0.96) | RAB9ANPC1ALDH1A1NOTUMSMN1; SMN2 | |
| SCHEMBL3081196 | 0.74 | RAB9A (0.61) | RAB9ANPC1ALDH1A1NOTUMSMN1; SMN2 | |
| SCHEMBL5157687 | 0.74 | RAB9A (0.61) | RAB9ANPC1ALDH1A1NOTUMSMN1; SMN2 | |
| SCHEMBL1013006 | 0.74 | RAB9A (0.61) | RAB9ANPC1ALDH1A1NOTUMSMN1; SMN2 | |
| SCHEMBL354607 | 0.74 | RAB9A (0.61) | RAB9ANPC1ALDH1A1NOTUMSMN1; SMN2 | |
| SCHEMBL27903378 | 0.74 | RAB9A (0.61) | RAB9ANPC1ALDH1A1NOTUMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6544982-B1 | 3-aryl-5-aminoisoxazole derivatives | MERCK & CO., INC. | 2003-04-08 | — | — | US | disclosed |
| US-6005116-A | HAVE INHIBITION ACTIVITIES AGAINST TYPE A-MONOAMINE OXIDASE; TREATING OR PREVENTING DEPRESSION, PARKINSON'S DISEASE, ALZEHEIMER'S DEMENTIA, OR CEREBROVASCULAR DEMENTIA | SANKYO COMPANY, LIMITED (JP) | 1999-12-21 | — | — | US | disclosed |
| CN-1216986-A | Isoxazole derivatives | SANKYO CO (JP) | 1999-05-19 | — | — | CN | disclosed |
| CN-1042225-C | Piperidyloxy-and quinuclidinyloxy-isoxazole derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 1999-02-24 | — | — | CN | disclosed |
| EP-0885891-A1 | ISOXAZOLE DERIVATIVES | SANKYO COMPANY LIMITED (JP) | 1998-12-23 | — | — | EP | disclosed |
| EP-0456519-B1 | Piperidyloxy- and quinuclidinyloxy- isoxazole derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 1994-07-13 | — | — | EP | disclosed |
| CN-1057259-A | Piperidines oxygen base and quinine epoxy group(ing) different oxazole derivatives, their preparation and the application aspect treatment thereof | SANKYO CO (JP) | 1991-12-25 | — | — | CN | disclosed |
| EP-0456519-A1 | Piperidyloxy- and quinuclidinyloxy- isoxazole derivatives, their preparation and their therapeutic use | Sankyo Company Limited (JP) | 1991-11-13 | — | — | EP | disclosed |
| US-4005202-A | 5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity | SYNTEX (U.S.A.) INC. (US) | 1977-01-25 | — | — | US | disclosed |
| US-3935209-A | 5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity | SYNTEX (U.S.A.) INC. (US) | 1976-01-27 | — | — | US | disclosed |