Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 2/20 | 0.48 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.48 |
| ▸ | SGK1 | O00141 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.36 |
| ▸ | CLK1 | P49759 | 3/20 | 0.36 |
| ▸ | METAP2 | P50579 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 3/20 | 0.35 |
| ▸ | LYN | P07948 | 3/20 | 0.35 |
| ▸ | AXL | P30530 | 3/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.35 |
| ▸ | ABL1 | P00519 | 2/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.35 |
| ▸ | LCK | P06239 | 2/20 | 0.35 |
| ▸ | FYN | P06241 | 2/20 | 0.35 |
| ▸ | CDK1 | P06493 | 2/20 | 0.35 |
| ▸ | CSF1R | P07333 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24005713 | 0.83 | PRMT5 (0.40) | PRMT5WDR77DYRK1ACLK1METAP2 | |
| SCHEMBL7443703 | 0.79 | PRMT5 (0.48) | PRMT5WDR77SGK1BTKIGF1R | |
| SCHEMBL29481417 | 0.79 | PRMT5 (0.48) | PRMT5WDR77SGK1BTKIGF1R | |
| Hydrochloric Acid SCHEMBL7213801 | 0.78 | PRMT5 (0.47) | PRMT5WDR77SGK1BTKIGF1R | |
| Hydrochloric Acid SCHEMBL29485586 | 0.78 | PRMT5 (0.47) | PRMT5WDR77SGK1BTKIGF1R | |
| Hydrochloric Acid SCHEMBL16881193 | 0.78 | PRMT5 (0.47) | PRMT5WDR77SGK1BTKIGF1R | |
| SCHEMBL30287195 | 0.73 | DYRK1A (0.43) | PRMT5WDR77DYRK1ACLK1METAP2 | |
| SCHEMBL25194118 | 0.73 | DYRK1A (0.43) | PRMT5WDR77DYRK1ACLK1METAP2 | |
| SCHEMBL13199598 | 0.73 | CYP3A4 (0.44) | PRMT5WDR77FLT3KITKDR | |
| SCHEMBL1565867 | 0.73 | DYRK1A (0.54) | PRMT5WDR77DYRK1ACLK1METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610692-B1 | Anticoagulants | MERCK & CO., INC. | 2003-08-26 | — | — | US | disclosed |
| EP-1124822-A4 | THROMBIN INHIBITORS | MERCK & CO INC (US) | 2002-04-03 | — | — | EP | disclosed |
| EP-1124822-A1 | THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 2001-08-22 | — | — | EP | disclosed |
| WO-2000026211-A1 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2000-05-11 | — | — | WO | disclosed |