SCHEMBL7222791

SCHEMBL7222791

N#CC1(c2cncc(Cl)c2)CC2CCC(C1)N2C(=S)S

nearest known ligand 0.35

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
OPRL1 P41146 1/20 0.35
NPSR1 Q6W5P4 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8184433 0.85 OPRL1 (0.36) OPRL1NPSR1
SCHEMBL8174171 0.85 OPRL1 (0.36) OPRL1NPSR1
SCHEMBL7222188 0.85 OPRL1 (0.33) OPRL1
SCHEMBL6573291 0.84 OPRL1 (0.38) OPRL1
SCHEMBL7222052 0.83 OPRL1 (0.35) OPRL1NPSR1
SCHEMBL7223809 0.83 GRM5 (0.36) OPRL1NPSR1
SCHEMBL8188621 0.82 NPSR1 (0.34) OPRL1NPSR1
SCHEMBL6574374 0.81 OPRL1 (0.38) OPRL1
SCHEMBL7230196 0.81 OPRL1 (0.38) OPRL1
SCHEMBL6617335 0.81 OPRL1 (0.41) OPRL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6573275-B1 Insecticidal compositions comprising and to methods of combatting and controlling insect pests therewith. SYNGENTA LIMITED (GB) 2003-06-03 US disclosed
EP-0828739-B1 BICYCLIC AMINES AS INSECTICIDES SYNGENTA LTD (GB) 2002-09-11 EP disclosed
US-6391883-B1 INSECTICIDES SYNGENTA LIMITED (GB) 2002-05-21 US disclosed
US-6207676-B1 Bicyclic amines ZENECA LIMITED (GB) 2001-03-27 US disclosed
EP-0828739-A1 BICYCLIC AMINES AS INSECTICIDES ZENECA LIMITED (GB) 1998-03-18 EP disclosed
WO-1996037494-A1 BICYCLIC AMINES AS INSECTICIDES ZENECA LIMITED (GB) 1996-11-28 WO disclosed