Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7225018 | 0.89 | SLC6A4 (0.33) | SLC6A4SLC6A3 | |
| SCHEMBL7223163 | 0.88 | SLC6A3 (0.32) | KDM1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7229680 | 0.86 | HPGD (0.36) | ALDH1A1HPGDKMT2ANPC1RAB9A | |
| SCHEMBL7225000 | 0.86 | NPC1 (0.34) | KMT2ANPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL7231162 | 0.85 | NPC1 (0.43) | ALDH1A1HPGDKMT2ANPC1RAB9A | |
| SCHEMBL7233218 | 0.85 | HPGD (0.34) | HPGDSMN1; SMN2 | |
| SCHEMBL7224129 | 0.85 | NPC1 (0.32) | NPC1RAB9ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7115039 | 0.84 | HDAC6 (0.38) | ALDH1A1HPGDKMT2ALMNANPC1 | |
| SCHEMBL7232207 | 0.83 | SLC6A2 (0.39) | HPGDNPC1RAB9ASMN1; SMN2SLC6A2 | |
| SCHEMBL7231839 | 0.83 | KDM1A (0.32) | HPGDKDM1AMAOAMAOBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |