Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 19/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | RXRB | P28702 | 9/20 | 0.44 |
| ▸ | RXRG | P48443 | 9/20 | 0.44 |
| ▸ | RARB | P10826 | 5/20 | 0.44 |
| ▸ | RARG | P13631 | 4/20 | 0.44 |
| ▸ | RARA | P10276 | 3/20 | 0.44 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.44 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8318880 | 0.84 | RXRA (0.57) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL12517022 | 0.77 | RXRA (0.52) | RXRAHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL13479239 | 0.75 | RXRA (0.54) | RXRAHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8320121 | 0.74 | RXRA (0.69) | RXRAHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL12517008 | 0.74 | RXRA (0.52) | RXRAHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8012501 | 0.73 | RXRA (0.51) | RXRAHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8324116 | 0.72 | RXRA (0.49) | RXRAHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8322151 | 0.72 | RXRA (0.44) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL7217242 | 0.71 | RXRA (0.70) | RXRAHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL9177491 | 0.71 | RXRA (0.70) | RXRAHDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6627652-B1 | Treatment of diseases or conditions of the type which are normally treated with retinoid-like compounds is disclosed, with pharmaceutical compositions containing an active compound which is a selective agonist of the RXR retinoid | ALLERGAN, INC. | 2003-09-30 | — | — | US | disclosed |
| US-6624188-B1 | Administered to treat or prevent one or more of the diseases and conditions selected from the group consisting of dermatoses, atherosclerosis and restenosis resulting from neointimal hyperproliferation, non-malignant and | ALLERGAN, INC. | 2003-09-23 | — | — | US | disclosed |
| EP-0688213-B1 | TREATMENT OF TUMORS WITH COMPOUNDS HAVING RXR RETINOID RECEPTOR AGONIST ACTIVITY | ALLERGAN INC (US) | 2001-12-12 | — | — | EP | disclosed |
| EP-1159961-A2 | Treatment of tumors with compounds having RxR retinoid receptor agonist activity | ALLERGAN, INC. (US) | 2001-12-05 | — | — | EP | disclosed |
| US-5399586-A | Treatment of mammals afflicted with tumors with compounds having RXR retinoid receptor agonist activity | ALLERGAN, INC. (US) | 1995-03-21 | — | — | US | disclosed |
| US-5324840-A | Skin disorders | ALLERGAN, INC. (US) | 1994-06-28 | — | — | US | disclosed |