Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARG | P13631 | 20/20 | 0.69 |
| ▸ | RARB | P10826 | 19/20 | 0.69 |
| ▸ | RARA | P10276 | 16/20 | 0.69 |
| ▸ | RXRA | P19793 | 6/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | NPC1 | O15118 | 1/20 | 0.69 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.69 |
| ▸ | GMNN | O75496 | 1/20 | 0.69 |
| ▸ | USP2 | O75604 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | TP53 | P04637 | 1/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.69 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.69 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.69 |
| ▸ | THPO | P40225 | 1/20 | 0.69 |
| ▸ | MTOR | P42345 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7225011 | 1.00 | RARG (0.69) | RARGRARBRARARXRAKDM4E | |
| SCHEMBL7225007 | 1.00 | RARG (0.69) | RARGRARBRARARXRAKDM4E | |
| SCHEMBL10671099 | 0.87 | RARB (0.51) | RARGRARBRARARXRAKDM4E | |
| SCHEMBL10671093 | 0.87 | RARB (0.51) | RARGRARBRARARXRAKDM4E | |
| SCHEMBL345071 | 0.82 | RARB (1.00) | RARGRARBRARARXRAKDM4E | |
| SCHEMBL29836848 | 0.82 | RARB (1.00) | RARGRARBRARARXRAKDM4E | |
| SCHEMBL2307487 | 0.82 | RARB (1.00) | RARGRARBRARARXRAKDM4E | |
| SCHEMBL5304297 | 0.82 | RARB (0.85) | RARGRARBRARARXRAKDM4E | |
| SCHEMBL5304306 | 0.82 | RARB (0.85) | RARGRARBRARARXRAKDM4E | |
| SCHEMBL177444 | 0.82 | RARB (1.00) | RARGRARBRARARXRAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0176032-B1 | TETRALIN DERIVATIVES, THEIR PREPARATION AND USE | BASF Aktiengesellschaft (DE) | 1990-03-07 | — | — | EP | claimed |
| US-4760174-A | Tetralin derivatives, their preparation and their use | BASF AKTIENGESELLSCHAFT (DE) | 1988-07-26 | — | — | US | claimed |
| US-6627652-B1 | Treatment of diseases or conditions of the type which are normally treated with retinoid-like compounds is disclosed, with pharmaceutical compositions containing an active compound which is a selective agonist of the RXR retinoid | ALLERGAN, INC. | 2003-09-30 | — | — | US | disclosed |
| US-6624188-B1 | Administered to treat or prevent one or more of the diseases and conditions selected from the group consisting of dermatoses, atherosclerosis and restenosis resulting from neointimal hyperproliferation, non-malignant and | ALLERGAN, INC. | 2003-09-23 | — | — | US | disclosed |
| US-5475113-A | Treatment of skin disorders, skin cancer | ALLERGAN, INC. (US) | 1995-12-12 | — | — | US | disclosed |
| US-5455265-A | For mammals; skin disorders, cancer, inflammatory disease, cardiovascular diorders, autoimmune diseases and others | ALLERGAN, INC. (US) | 1995-10-03 | — | — | US | disclosed |
| US-5324840-A | Skin disorders | ALLERGAN, INC. (US) | 1994-06-28 | — | — | US | disclosed |
| US-4760174-A | Tetralin derivatives, their preparation and their use | BASF AKTIENGESELLSCHAFT (DE) | 1988-07-26 | — | — | US | disclosed |