Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 8/20 | 0.82 |
| ▸ | MMP3 | P08254 | 8/20 | 0.82 |
| ▸ | MMP9 | P14780 | 8/20 | 0.82 |
| ▸ | MMP13 | P45452 | 8/20 | 0.82 |
| ▸ | MMP1 | P03956 | 5/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7223278 | 0.92 | MMP2 (0.82) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL7223589 | 0.90 | MMP2 (1.00) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL7224963 | 0.89 | MMP2 (0.81) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL6292126 | 0.86 | MMP2 (0.64) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL7231571 | 0.85 | MMP2 (0.71) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL7223222 | 0.85 | MMP2 (0.71) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL7232243 | 0.83 | MMP2 (0.68) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL7223434 | 0.83 | MMP2 (1.00) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL7222078 | 0.79 | MMP2 (1.00) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL7551832 | 0.79 | MMP2 (0.62) | MMP2MMP3MMP9MMP13MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6605604-B1 | Tumour necrosis factor alpha release inhibitors; efficiency treatment of cancers, rheumatic diseases, arthritis, ulcers, atherosclerosis, asthma | LES LABORATOIRES SERVIER (FR) | 2003-08-12 | — | — | US | disclosed |