Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 1/20 | 0.42 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.42 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.36 |
| ▸ | PAOX | Q6QHF9 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | TLR2 | O60603 | 6/20 | 0.35 |
| ▸ | RRM1 | P23921 | 1/20 | 0.35 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
| ▸ | GSR | P00390 | 1/20 | 0.33 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | KDM4A | O75164 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.31 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7225433 | 0.85 | GNAI3 (0.39) | GNAI3GNAO1GNAI1DPP7PAOX | |
| SCHEMBL7227344 | 0.84 | GNAI3 (0.40) | GNAI3GNAO1GNAI1DPP7PAOX | |
| SCHEMBL7909580 | 0.80 | MEN1 (0.36) | GNAI3GNAO1GNAI1DPP7RRM1 | |
| SCHEMBL7901702 | 0.80 | DPP7 (0.41) | GNAI3GNAO1GNAI1DPP7PAOX | |
| SCHEMBL8759024 | 0.79 | GSR (0.52) | GNAI3GNAO1GNAI1DPP7CYP1A2 | |
| SCHEMBL8193777 | 0.79 | DPP7 (0.43) | GNAI3GNAO1GNAI1DPP7RRM1 | |
| SCHEMBL27972337 | 0.78 | CYP1A2 (0.47) | GNAI3GNAO1GNAI1DPP7CYP1A2 | |
| SCHEMBL7224815 | 0.76 | DPP7 (0.38) | GNAI3GNAO1GNAI1DPP7CYP1A2 | |
| SCHEMBL1065054 | 0.76 | GSR (0.52) | GNAI3GNAO1GNAI1DPP7PAOX | |
| SCHEMBL8950857 | 0.76 | GSR (0.52) | GNAI3GNAO1GNAI1DPP7CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6576780-B1 | Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors | GD SEARLE & COMPANY | 2003-06-10 | — | — | US | disclosed |
| US-6207708-B1 | FOR THERAPY AND PROPHYLAXIS OF AUTOIMMUNE AND/OR INFLAMMATORY CONDITIONS AFFECTING THE JOINTS SUCH AS ARTHRITIS, AND INFLAMMATORY BOWEL DISEASE, CARDIVASCULAR ISCHEMIA, DIABETES, CONGESTIVE HEART FAILURE, MYOCARDITIS, ATHEROSCLEROSIS, | G. D. SEARLE & COMPANY | 2001-03-27 | — | — | US | disclosed |
| EP-0885188-B1 | HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | SEARLE & CO (US) | 2000-09-27 | — | — | EP | disclosed |
| WO-1997032844-A9 | HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | — | 1997-12-24 | — | — | WO | disclosed |