Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 10/20 | 0.44 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 5/20 | 0.40 |
| ▸ | HTR3B | O95264 | 5/20 | 0.40 |
| ▸ | HTR3A | P46098 | 5/20 | 0.40 |
| ▸ | HTR3D | Q70Z44 | 5/20 | 0.40 |
| ▸ | HTR3C | Q8WXA8 | 5/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7225752 | 0.88 | CHRNA7 (0.45) | CHRNA7HSD17B1HSD17B2DYRK1ADYRK1B | |
| SCHEMBL7226736 | 0.87 | DYRK1A (0.44) | CHRNA7DYRK1ADYRK1BHTR3EHTR3B | |
| SCHEMBL7223518 | 0.87 | CHRNA7 (0.60) | CHRNA7DYRK1ADYRK1BHTR3EHTR3B | |
| SCHEMBL7225664 | 0.87 | HPGD (0.48) | CHRNA7HSD17B1HSD17B2DYRK1ADYRK1B | |
| Hydrochloric Acid SCHEMBL7226319 | 0.86 | CHRNA7 (0.59) | CHRNA7DYRK1ADYRK1BHTR3EHTR3B | |
| SCHEMBL7231719 | 0.85 | CHRNA7 (0.42) | CHRNA7DYRK1ADYRK1BHTR3EHTR3B | |
| SCHEMBL7223890 | 0.85 | CHRNA7 (0.43) | CHRNA7DYRK1ADYRK1BHTR3EHTR3B | |
| SCHEMBL7232588 | 0.85 | HPGD (0.50) | CHRNA7DYRK1ADYRK1BHTR3EHTR3B | |
| SCHEMBL7223981 | 0.84 | CHRNA7 (0.42) | CHRNA7DYRK1ADYRK1BHTR3EHTR3B | |
| SCHEMBL7232275 | 0.84 | CHRNA7 (0.62) | CHRNA7HSD17B1HSD17B2HTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |