SCHEMBL7226505

SCHEMBL7226505

CC(=O)N1CCC(CCC(=O)c2ccc3c(c2)CCN(C=O)CC3)CC1

nearest known ligand 0.52

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MCHR1 Q99705 8/20 0.52
ACHE P22303 11/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7227560 0.90 MCHR1 (0.50) MCHR1ACHE
SCHEMBL7234380 0.89 ACHE (0.50) MCHR1ACHE
SCHEMBL7226175 0.84 ACHE (0.67) MCHR1ACHE
Hydrochloric Acid SCHEMBL7236049 0.84 ACHE (0.54) MCHR1ACHE
Hydrochloric Acid SCHEMBL7235576 0.84 MCHR1 (0.52) MCHR1ACHE
SCHEMBL7227558 0.83 ACHE (0.72) ACHE
SCHEMBL7227360 0.83 MCHR1 (0.59) MCHR1ACHE
Hydrochloric Acid SCHEMBL7226249 0.83 ACHE (0.71) ACHE
SCHEMBL7226191 0.83 MCHR1 (0.51) MCHR1ACHE
Hydrochloric Acid SCHEMBL7227093 0.81 ACHE (0.54) MCHR1ACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6534496-B1 Prophylactic and/or therapeutic drug for obesity and obesity associated diseasestor diabetes with a reduced risk for central side effects and high universality in usage. Another object of the a lipolytic agent, or a prophylactic and/or TAKEDA CHEMICAL INDUSTRIES, INC. (JP) 2003-03-18 US disclosed
EP-0975624-A1 THERMOGENIC COMPOSITION AND BENZAZEPINE THERMOGENICS Takeda Chemical Industries, Ltd. (JP) 2000-02-02 EP disclosed
WO-1998046590-A1 THERMOGENIC COMPOSITION AND BENZAZEPINE THERMOGENICS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-10-22 WO disclosed