Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7226539 | 1.00 | LMNA (0.63) | LMNAKDM4EMEN1KMT2AGAA | |
| SCHEMBL7226534 | 1.00 | LMNA (0.63) | LMNAKDM4EMEN1KMT2AGAA | |
| SCHEMBL10587075 | 0.81 | LMNA (0.61) | LMNAKDM4EMEN1KMT2AGAA | |
| SCHEMBL28026427 | 0.78 | CYP2D6 (0.50) | LMNAOPRM1CYP2D6SIGMAR1 | |
| SCHEMBL28798434 | 0.77 | SLC18A3 (0.56) | LMNAKDM4EMEN1KMT2AGAA | |
| SCHEMBL8013931 | 0.77 | LMNA (0.86) | LMNAKDM4EMEN1KMT2AGAA | |
| SCHEMBL11548258 | 0.76 | KDM4E (0.62) | KDM4EMEN1KMT2ACYP2D6HIF1A | |
| Hydrochloric Acid SCHEMBL8017732 | 0.76 | LMNA (0.84) | LMNAKDM4EMEN1KMT2AGAA | |
| SCHEMBL10587085 | 0.74 | LMNA (0.54) | LMNAKDM4EMEN1KMT2AGAA | |
| SCHEMBL1205842 | 0.73 | GAA (0.71) | KDM4EMEN1KMT2AGAAOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6642231-B2 | Antineoplastic agents, treatment for neuronal injury and degeneration | AVENTIS PHARMACEUTICALS INC. | 2003-11-04 | — | — | US | disclosed |