Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | AKT2 | P31751 | 5/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 4/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 2/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | FCER2 | P06734 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7227041 | 1.00 | KDM1A (0.39) | KDM1ARCOR1ROCK2KITPDGFRA | |
| SCHEMBL6978475 | 0.90 | MEN1 (0.40) | KDM1ARCOR1ROCK2KITPDGFRA | |
| SCHEMBL6978482 | 0.90 | MEN1 (0.40) | KDM1ARCOR1ROCK2KITPDGFRA | |
| SCHEMBL7225609 | 0.89 | JAK3 (0.42) | KDM1ARCOR1ROCK2KITPDGFRA | |
| SCHEMBL7225613 | 0.89 | JAK3 (0.42) | KDM1ARCOR1ROCK2KITPDGFRA | |
| SCHEMBL7224414 | 0.89 | ROCK2 (0.41) | ROCK2AKT2PDPK1AKT1FCER2 | |
| SCHEMBL7224411 | 0.89 | ROCK2 (0.41) | ROCK2AKT2PDPK1AKT1FCER2 | |
| SCHEMBL7232079 | 0.87 | BRD4 (0.40) | KDM1ARCOR1KITPDGFRAKDR | |
| SCHEMBL7232075 | 0.87 | BRD4 (0.40) | KDM1ARCOR1KITPDGFRAKDR | |
| SCHEMBL7225072 | 0.85 | KIT (0.38) | KDM1ARCOR1KITPDGFRAKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6545035-B1 | Having effect on various kinases and cycline/CDK complexes and on the proliferation of various tumour cells. | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-04-08 | — | — | US | disclosed |
| US-6319918-B1 | FOR LYMPHOMA OR SOLID TUMORS TREATMENT | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-11-20 | — | — | US | disclosed |