Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 9/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 9/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 9/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 9/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 9/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 9/20 | 0.47 |
| ▸ | F10 | P00742 | 6/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7227598 | 0.93 | GRM2 (0.50) | GRM2ITGB3PRSS1PRSS2ITGA2B | |
| SCHEMBL7235063 | 0.90 | GRM2 (0.50) | GRM2ITGB3PRSS1PRSS2ITGA2B | |
| SCHEMBL7229207 | 0.90 | GRM2 (0.48) | GRM2ITGB3PRSS1PRSS2ITGA2B | |
| SCHEMBL7229838 | 0.90 | GRM2 (0.48) | GRM2ITGB3PRSS1PRSS2ITGA2B | |
| SCHEMBL7229073 | 0.90 | GRM2 (0.45) | GRM2ITGB3PRSS1PRSS2ITGA2B | |
| SCHEMBL7239022 | 0.89 | GRM2 (0.49) | GRM2ITGB3PRSS1PRSS2ITGA2B | |
| SCHEMBL7229940 | 0.88 | GRM2 (0.51) | GRM2ITGB3PRSS1PRSS2ITGA2B | |
| SCHEMBL7236076 | 0.85 | ITGB3 (0.50) | GRM2ITGB3PRSS1PRSS2ITGA2B | |
| SCHEMBL7229200 | 0.85 | ITGB3 (0.50) | GRM2ITGB3PRSS1PRSS2ITGA2B | |
| SCHEMBL7227714 | 0.84 | GRM2 (0.51) | GRM2ITGB3PRSS1PRSS2ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6602876-B1 | Adhesion receptor antagonists | MERCK PATENT GMBH (DE) | 2003-08-05 | — | — | US | disclosed |
| EP-0710657-B1 | Antagonists of adhesion receptors | MERCK PATENT GMBH (DE) | 1998-08-26 | — | — | EP | disclosed |
| EP-0710657-A1 | Antagonists of adhesion receptors | MERCK PATENT GmbH (DE) | 1996-05-08 | — | — | EP | disclosed |