Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.60 |
| ▸ | CDK7 | P50613 | 2/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7230509 | 0.94 | KDR (0.56) | KDRCDK7ABL1LCKCSF1R | |
| SCHEMBL6180720 | 0.85 | KDR (0.66) | KDRCDK7ABL1LCKCSF1R | |
| SCHEMBL7236876 | 0.83 | KDR (0.58) | KDRCDK7ABL1LCKCSF1R | |
| SCHEMBL7237730 | 0.79 | KDR (0.56) | KDRCDK7ABL1LCKCSF1R | |
| SCHEMBL7235020 | 0.78 | KDR (0.54) | KDRCDK7ABL1LCKCSF1R | |
| SCHEMBL6180700 | 0.78 | KDR (0.65) | KDRCDK7ABL1LCKCSF1R | |
| SCHEMBL7237397 | 0.76 | KDR (1.00) | KDRCDK7ABL1LCKCSF1R | |
| SCHEMBL17539705 | 0.76 | KDR (0.55) | KDRABL1PDGFRBKITFLT3 | |
| Bromide SCHEMBL29350593 | 0.75 | KDR (0.54) | KDRABL1PDGFRBKITFLT3 | |
| SCHEMBL27584823 | 0.75 | KDR (0.61) | KDRCDK7ABL1LCKCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6586424-B2 | Anticancer agents; anticholesterol agents | MERCK & CO., INC. | 2003-07-01 | — | — | US | disclosed |
| US-6586423-B2 | 2-(Pyridin-2-ylamino)-thiazole-5-carbonitrile derivatives; angiogenesis inhibitors; antitumor and anticarcinogenic agents; atherosclerosis, macular degeneration, diabetic retinopathy | MERCK & CO., INC. | 2003-07-01 | — | — | US | disclosed |