Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.55 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL29350593 | 0.99 | KDR (0.54) | KDRNAMPTMEN1NPC1RAB9A | |
| SCHEMBL15587693 | 0.82 | RAB9A (0.62) | MEN1NPC1RAB9AKMT2APOLB | |
| SCHEMBL19451200 | 0.80 | RAB9A (0.49) | MEN1NPC1RAB9AKMT2A | |
| SCHEMBL17539710 | 0.80 | KDR (0.60) | KDRNAMPTMEN1NPC1RAB9A | |
| SCHEMBL7236876 | 0.78 | KDR (0.58) | KDRABL1PDGFRB | |
| SCHEMBL24225743 | 0.77 | KDR (0.40) | KDRNAMPTHDAC3ABL1PDGFRB | |
| SCHEMBL7237730 | 0.77 | KDR (0.56) | KDRNAMPTABL1PDGFRBKIT | |
| SCHEMBL17539298 | 0.76 | RAB9A (0.66) | MEN1NPC1RAB9AKMT2APOLB | |
| SCHEMBL7228017 | 0.76 | KDR (0.60) | KDRABL1PDGFRBKITFLT3 | |
| SCHEMBL7230509 | 0.75 | KDR (0.56) | KDRNAMPTABL1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11058707-B2 | Methods for treating ischemic heart disease by targeting TRPV4 | NORTHEAST OHIO MEDICAL UNIVERSITY (US) | 2021-07-13 | — | — | US | claimed |
| US-11564911-B2 | Small molecule dual-inhibitors of TRPV4 and TRPA1 for sanitizing and anesthetizing | DUKE UNIVERSITY (US) | 2023-01-31 | — | — | US | disclosed |
| US-11229628-B2 | TRPA1 and TRPV4 inhibitors and methods of using the same for organ-specific inflammation and itch | DUKE UNIVERSITY (US) | 2022-01-25 | — | — | US | disclosed |
| US-11058707-B2 | Methods for treating ischemic heart disease by targeting TRPV4 | NORTHEAST OHIO MEDICAL UNIVERSITY (US) | 2021-07-13 | — | — | US | disclosed |
| US-11014896-B2 | TRPA1 and TRPV4 inhibitors and methods of using the same for organ-specific inflammation and itch | DUKE UNIVERSITY (US) | 2021-05-25 | — | — | US | disclosed |
| US-20190315700-A1 | TRPA1 AND TRPV4 INHIBITORS AND METHODS OF USING THE SAME FOR ORGAN-SPECIFIC INFLAMMATION AND ITCH | DUKE UNIVERSITY | 2019-10-17 | — | — | US | disclosed |
| US-10329265-B2 | TRPA1 and TRPV4 inhibitors and methods of using the same for organ-specific inflammation and itch | DUKE UNIVERSITY (US) | 2019-06-25 | — | — | US | disclosed |
| US-20190091206-A1 | SMALL MOLECULE DUAL-INHIBITORS OF TRPV4 AND TRPA1 FOR SANITIZING AND ANESTHETIZING | DUKE UNIVERSITY | 2019-03-28 | — | — | US | disclosed |
| WO-2017177200-A1 | SMALL MOLECULE DUAL-INHIBITORS OF TRPV4 AND TRPA1 FOR SANITIZING AND ANESTHETIZING | DUKE UNIVERSITY (US) | 2017-10-12 | — | — | WO | disclosed |
| US-20170267651-A1 | TRPA1 AND TRPV4 INHIBITORS AND METHODS OF USING THE SAME FOR ORGAN-SPECIFIC INFLAMMATION AND ITCH | DUKE UNIVERSITY | 2017-09-21 | — | — | US | disclosed |
| US-20170267651-A1 | TRPA1 AND TRPV4 INHIBITORS AND METHODS OF USING THE SAME FOR ORGAN-SPECIFIC INFLAMMATION AND ITCH | DUKE UNIVERSITY | 2017-09-21 | — | — | US | disclosed |
| US-20160199363-A1 | TRPA1 AND TRPV4 INHIBITORS AND METHODS OF USING THE SAME FOR ORGAN-SPECIFIC INFLAMMATION AND ITCH | DUKE UNIVERSITY | 2016-07-14 | — | — | US | disclosed |
| US-20160199363-A1 | TRPA1 AND TRPV4 INHIBITORS AND METHODS OF USING THE SAME FOR ORGAN-SPECIFIC INFLAMMATION AND ITCH | DUKE UNIVERSITY | 2016-07-14 | — | — | US | disclosed |
| WO-2016028325-A1 | TRPA1 AND TRPV4 INHIBITORS AND METHODS OF USING THE SAME FOR ORGAN-SPECIFIC INFLAMMATION AND ITCH | DUKE UNIVERSITY (US) | 2016-02-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190315700-A1 | TRPA1 AND TRPV4 INHIBITORS AND METHODS OF USING THE SAME FOR ORGAN-SPECIFIC INFLAMMATION AND ITCH | TRPA1, TRPV4, TRPV2 | KDR 2432/4885NAMPT 657/4885MEN1 4720/4885 |
| US-20160199363-A1 | TRPA1 AND TRPV4 INHIBITORS AND METHODS OF USING THE SAME FOR ORGAN-SPECIFIC INFLAMMATION AND ITCH | TRPA1, TRPV4, TRPV2 | KDR 2432/4885NAMPT 657/4885MEN1 4720/4885 |
| US-20170267651-A1 | TRPA1 AND TRPV4 INHIBITORS AND METHODS OF USING THE SAME FOR ORGAN-SPECIFIC INFLAMMATION AND ITCH | TRPA1, TRPV4, TRPV2 | KDR 2432/4885NAMPT 657/4885MEN1 4720/4885 |
| US-11229628-B2 | TRPA1 and TRPV4 inhibitors and methods of using the same for organ-specific inflammation and itch | TRPA1, TRPV4, TRPV2 | KDR 2432/4885NAMPT 657/4885MEN1 4720/4885 |
| US-11564911-B2 | Small molecule dual-inhibitors of TRPV4 and TRPA1 for sanitizing and anesthetizing | TRPA1, TRPV4, TRPV1 | KDR 2359/4885NAMPT 1466/4885MEN1 4823/4885 |
| US-10329265-B2 | TRPA1 and TRPV4 inhibitors and methods of using the same for organ-specific inflammation and itch | TRPA1, TRPV4, TRPV2 | KDR 2432/4885NAMPT 657/4885MEN1 4720/4885 |
| US-20190091206-A1 | SMALL MOLECULE DUAL-INHIBITORS OF TRPV4 AND TRPA1 FOR SANITIZING AND ANESTHETIZING | TRPA1, TRPV4, TRPV1 | KDR 2359/4885NAMPT 1466/4885MEN1 4823/4885 |
| US-11014896-B2 | TRPA1 and TRPV4 inhibitors and methods of using the same for organ-specific inflammation and itch | TRPA1, TRPV4, TRPV2 | KDR 2432/4885NAMPT 657/4885MEN1 4720/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.