SCHEMBL7228100

SCHEMBL7228100

CC/C(=N/OC)c1cc(C)nc(Oc2c(OC)cc(C)cc2OC)c1C

nearest known ligand 0.43

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CRHR1 P34998 3/20 0.39
ACHE P22303 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7220512 1.00 CRHR1 (0.39) CRHR1ACHE
SCHEMBL7220510 1.00 CRHR1 (0.39) CRHR1ACHE
SCHEMBL7221854 0.92 CRHR1 (0.34) CRHR1
SCHEMBL7222681 0.92 CRHR1 (0.34) CRHR1
SCHEMBL7221856 0.92 CRHR1 (0.34) CRHR1
SCHEMBL7220325 0.88 CRHR1 (0.49) CRHR1
SCHEMBL7220327 0.88 CRHR1 (0.49) CRHR1
SCHEMBL7221848 0.88 CRHR1 (0.49) CRHR1
SCHEMBL7219498 0.83 CRHR1 (0.39) CRHR1
SCHEMBL7222538 0.83 CRHR1 (0.39) CRHR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1103553-A2 Substituted heterocyclic derivatives Pfizer Products Inc. (US) 2001-05-30 EP claimed
US-6525067-B1 Corticotropin releasing factor antagonists; such as 1-(2-methyl-8-(2,4,6-trimethyl-phenyl)-quinolin-4-yl)-propan-1-one-oxime PFIZER INC 2003-02-25 US disclosed
EP-1103553-A2 Substituted heterocyclic derivatives Pfizer Products Inc. (US) 2001-05-30 EP disclosed