Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | MMP7 | P09237 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7011877 | 0.75 | SMN1; SMN2 (0.42) | SMN1; SMN2HPGDLMNATSHRPOLB | |
| SCHEMBL20400928 | 0.71 | STAT3 (0.41) | LMNAPOLBALDH1A1HTTMMP13 | |
| SCHEMBL13037005 | 0.70 | PSEN1 (0.49) | SMN1; SMN2HPGDLMNATSHRPOLB | |
| SCHEMBL20507216 | 0.69 | CHRM4 (0.66) | SMN1; SMN2HPGDLMNATSHRPOLB | |
| SCHEMBL6214472 | 0.69 | TSHR (0.66) | SMN1; SMN2HPGDLMNATSHRPOLB | |
| SCHEMBL5702094 | 0.68 | ALDH1A1 (0.62) | HPGDLMNATSHRPOLBALDH1A1 | |
| SCHEMBL5702221 | 0.68 | ALDH1A1 (0.62) | HPGDLMNATSHRPOLBALDH1A1 | |
| SCHEMBL4669530 | 0.68 | ALDH1A1 (0.62) | HPGDLMNATSHRPOLBALDH1A1 | |
| SCHEMBL4182416 | 0.67 | MAPK1 (0.62) | SMN1; SMN2HPGDLMNATSHRPOLB | |
| SCHEMBL17327489 | 0.66 | ALDH1A1 (0.41) | LMNAPOLBALDH1A1HTTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6645939-B1 | Very late antigen-4 (VLA) integrin antagonists; antiallergens, antiasthmatics, and antiinflammatory agents; multiple sclerosis, autoimmune disease treatment | MERCK & CO., INC. | 2003-11-11 | — | — | US | disclosed |