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SCHEMBL7228192

SCHEMBL7228192

COc1cc(C=NNC(=O)c2ccc(O)c(Cl)c2)ccc1NC(=O)C(C)(C)Oc1ccc(Cl)cc1

nearest known ligand 0.68

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ GCGR P47871 11/20 0.68
▸ ADCYAP1R1 P41586 5/20 0.51
▸ MEN1 O00255 2/20 0.49
▸ KMT2A Q03164 2/20 0.49
▸ ALDH1A1 P00352 1/20 0.49
▸ POLB P06746 1/20 0.49
▸ GAA P10253 1/20 0.49
▸ MAPT P10636 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9072061 0.81 GCGR (1.00) GCGRADCYAP1R1
SCHEMBL22221453 0.81 GCGR (0.56) GCGRMEN1KMT2AALDH1A1POLB
SCHEMBL7228188 0.79 TP53 (0.43) GCGRALDH1A1POLBMAPT
SCHEMBL2650470 0.76 GCGR (0.64) GCGRADCYAP1R1MEN1KMT2APOLB
SCHEMBL2649370 0.76 GCGR (0.61) GCGRADCYAP1R1MEN1KMT2AALDH1A1
SCHEMBL2650467 0.75 GCGR (0.62) GCGRADCYAP1R1MEN1KMT2AALDH1A1
SCHEMBL9072060 0.75 GCGR (0.60) GCGRADCYAP1R1MEN1KMT2AALDH1A1
SCHEMBL24697396 0.74 SMN1; SMN2 (0.51) GCGRMEN1KMT2AALDH1A1POLB
SCHEMBL2649191 0.74 ADCYAP1R1 (0.65) GCGRADCYAP1R1MEN1KMT2AALDH1A1
SCHEMBL2649190 0.74 ADCYAP1R1 (0.65) GCGRADCYAP1R1MEN1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6613942-B1 Nonpeptide; 4-hydroxy benzoic acid hydrazides NOVO NORDISK A/S (DK) 2003-09-02 — — US disclosed