Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 16/20 | 0.40 |
| ▸ | FNTB | P49356 | 16/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 12/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.40 |
| ▸ | PGGT1B | P53609 | 11/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7228811 | 0.99 | FNTA (0.39) | FNTAFNTBKCNH2CYP3A4PGGT1B | |
| SCHEMBL7253295 | 0.70 | FNTA (0.51) | FNTAFNTBKCNH2CYP3A4PGGT1B | |
| Hydrochloric Acid SCHEMBL7252683 | 0.69 | FNTA (0.51) | FNTAFNTBKCNH2CYP3A4PGGT1B | |
| SCHEMBL7248216 | 0.69 | FNTA (0.51) | FNTAFNTBKCNH2CYP3A4PGGT1B | |
| SCHEMBL7252273 | 0.69 | FNTA (0.51) | FNTAFNTBKCNH2CYP3A4PGGT1B | |
| Hydrochloric Acid SCHEMBL7248127 | 0.68 | FNTA (0.50) | FNTAFNTBKCNH2CYP3A4PGGT1B | |
| Hydrochloric Acid SCHEMBL7247014 | 0.68 | FNTA (0.50) | FNTAFNTBKCNH2CYP3A4PGGT1B | |
| Hydrochloric Acid SCHEMBL7253913 | 0.68 | FNTA (0.50) | FNTAFNTBKCNH2CYP3A4PGGT1B | |
| SCHEMBL7248670 | 0.64 | FNTA (0.61) | FNTAFNTBPGGT1B | |
| Hydrochloric Acid SCHEMBL7251284 | 0.63 | FNTA (0.61) | FNTAFNTBPGGT1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610722-B2 | Peptidomimetic macrocyclic compounds that comprise a bicyclic imidazolyl moiety and that do not contain thiol moieties; e.g., 3,5-ethano-6,10:12,16-dimetheno-22H-imidazo (3,4-h)(1,8,11,14)oxatriazacycloeicosine-9-carbonitrile | MERCK & CO., INC. | 2003-08-26 | — | — | US | claimed |
| US-6610722-B2 | Peptidomimetic macrocyclic compounds that comprise a bicyclic imidazolyl moiety and that do not contain thiol moieties; e.g., 3,5-ethano-6,10:12,16-dimetheno-22H-imidazo (3,4-h)(1,8,11,14)oxatriazacycloeicosine-9-carbonitrile | MERCK & CO., INC. | 2003-08-26 | — | — | US | disclosed |
| US-20020068747-A1 | Inhibitors of prenyl-protein transferase | MERCK SHARP & DOHME CORP. | 2002-06-06 | — | — | US | disclosed |
| WO-2001077114-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2001-10-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020068747-A1 | Inhibitors of prenyl-protein transferase | FNTA, KRAS, NRAS | FNTA 1/4885FNTB 4/4885KCNH2 4800/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.