Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | MPC2 | O95563 | 1/20 | 0.44 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7228269 | 0.91 | MAPT (0.47) | PPARGMAPTMPC2CYP2C8CYP2C9 | |
| SCHEMBL7223192 | 0.91 | PPARG (0.47) | PPARGMAPTMPC2CYP2C8CYP2C9 | |
| SCHEMBL7228500 | 0.89 | ABCB1 (0.46) | PPARGMAPTACHEMPC2CYP2C8 | |
| SCHEMBL7221407 | 0.82 | KMT2A (0.42) | PPARGMAPTBCHEMPC2CYP2C8 | |
| SCHEMBL7221825 | 0.81 | MAPT (0.47) | MAPTMAOAPOLBTHRBTP53 | |
| SCHEMBL7228191 | 0.81 | POLH (0.41) | PPARGMAPTMPC2CYP2C8CYP2C9 | |
| SCHEMBL7228016 | 0.81 | POLH (0.45) | PPARGMAPTACHEMAOAFFAR1 | |
| SCHEMBL7223493 | 0.81 | MAPT (0.45) | PPARGMAPTMAOAPOLBTP53 | |
| SCHEMBL7220586 | 0.80 | POLH (0.59) | PPARGMAPTMPC2CYP2C8CYP2C9 | |
| SCHEMBL7237476 | 0.80 | POLH (0.46) | PPARGMAPTMPC2CYP2C8CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6552054-B1 | For prophylaxis and therapy of bone diseases and chondropathy | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-04-22 | — | — | US | disclosed |
| EP-1211251-A1 | CHROMONE DERIVATIVES, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2002-06-05 | — | — | EP | disclosed |