Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7229022 | 0.95 | DAO (0.36) | DAOMAOAMAOBHTTALDH1A1 | |
| SCHEMBL7228682 | 0.85 | MAOB (0.41) | MAOAMAOBHTTALDH1A1 | |
| SCHEMBL7239679 | 0.83 | MAOB (0.40) | MAOAMAOBHTTALDH1A1 | |
| SCHEMBL7767848 | 0.82 | DAO (0.41) | DAOMAOAMAOBHTTALDH1A1 | |
| SCHEMBL7228810 | 0.81 | TAAR1 (0.41) | MAOBKCNH2 | |
| SCHEMBL80232 | 0.80 | DAO (0.42) | DAOHTTALDH1A1TRPV3 | |
| SCHEMBL7229152 | 0.79 | MAOB (0.39) | MAOAMAOBHTTALDH1A1 | |
| SCHEMBL9574248 | 0.79 | TAAR1 (0.39) | MAOBKCNH2 | |
| SCHEMBL29447904 | 0.76 | DAO (0.44) | DAOMAOAMAOBHTTALDH1A1 | |
| SCHEMBL3120224 | 0.76 | DAO (0.44) | DAOMAOAMAOBHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6531469-B1 | Treatment of myocardial ischemia, chronic stable angina, unstable angina and prinzmetal's angina attacks, silent cardiac ischemia, reinfarction, reocclusion and restenosis | PIERRE FABRE MEDICAMENT (FR) | 2003-03-11 | — | — | US | disclosed |
| EP-1144408-B1 | SUBSTITUTED 1-(PIERIDIN-4-YL)-3-(ARYL) ISOTHIOUREAS THEIR PREPARATION AND THERAPEUTIC APPLICATION | PF MEDICAMENT (FR) | 2002-09-25 | — | — | EP | disclosed |
| EP-1144408-A1 | SUBSTITUTED 1-(PIERIDIN-4-YL)-3-(ARYL) ISOTHIOUREAS THEIR PREPARATION AND THERAPEUTIC APPLICATION | PIERRE FABRE MEDICAMENT (FR) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000043391-A1 | SUBSTITUTED 1-(PIERIDIN-4-YL)-3-(ARYL) ISOTHIOUREAS THEIR PREPARATION AND THERAPEUTIC APPLICATION | PIERRE FABRE MEDICAMENT (FR) | 2000-07-27 | — | — | WO | disclosed |