Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | AGXT | P21549 | 1/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7228810 | 0.98 | TAAR1 (0.41) | TAAR1SIRT2KCNH2MAOBELOVL1 | |
| SCHEMBL9574237 | 0.93 | TAAR1 (0.39) | TAAR1SIRT2KCNH2MAOBCHRM2 | |
| SCHEMBL7239327 | 0.85 | TAAR1 (0.42) | TAAR1KCNH2MAOBIDO1AGXT | |
| SCHEMBL7230360 | 0.84 | IDO1 (0.44) | MAOBIDO1AGXT | |
| SCHEMBL7741926 | 0.84 | IDO1 (0.44) | MAOBIDO1AGXT | |
| SCHEMBL8722410 | 0.83 | TAAR1 (0.46) | TAAR1MAOBIDO1AGXT | |
| SCHEMBL11669981 | 0.83 | TAAR1 (0.46) | TAAR1MAOBIDO1AGXT | |
| SCHEMBL28367193 | 0.82 | TAAR1 (0.54) | TAAR1MAOBELOVL1IDO1AGXT | |
| SCHEMBL9574215 | 0.82 | KCNH2 (0.43) | TAAR1KCNH2 | |
| SCHEMBL9764482 | 0.82 | KCNH2 (0.54) | TAAR1KCNH2IDO1AGXTCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5243076-A | Adrenergic stimulant intermediates | GLAXO GROUP LTD. | 1993-09-07 | — | — | US | disclosed |
| US-5225445-A | Respiratory system disorders | GLAXO GROUP LTD. | 1993-07-06 | — | — | US | disclosed |
| US-5126375-A | Asthma, chronic bronchitis | GLAXO GROUP LTD. (GB) | 1992-06-30 | — | — | US | disclosed |
| US-5091422-A | Treating inflammatory or allergic skin disease, lowering gastric acidity | GLAXO GROUP LIMITED (GB) | 1992-02-25 | — | — | US | disclosed |
| US-5006556-A | Dichloroaniline derivatives for the therapy or prophylaxysis of a disease associated with reversible airway obstruction | GLAXO GROUP LIMITED (GB) | 1991-04-09 | — | — | US | disclosed |
| US-4992474-A | Adrenergic stimulants | GLAXO GROUP LTD. (GB) | 1991-02-12 | — | — | US | disclosed |
| US-4943591-A | TREATMENT OF ASTHMA AND BRONCHITIS | GLAXO GROUP LIMITED (GB) | 1990-07-24 | — | — | US | disclosed |
| EP-0181709-B1 | DICHLOROANILINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1990-05-09 | — | — | EP | disclosed |
| EP-0181709-A1 | Dichloroaniline Derivatives | GLAXO GROUP LIMITED (GB) | 1986-05-21 | — | — | EP | disclosed |