Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.58 |
| ▸ | CCR6 | P51684 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7237851 | 0.78 | KDR (0.62) | KDR | |
| SCHEMBL7235297 | 0.78 | KDR (0.62) | KDR | |
| SCHEMBL7235235 | 0.75 | KDR (0.58) | KDR | |
| SCHEMBL7235024 | 0.74 | KDR (0.65) | KDR | |
| SCHEMBL6179910 | 0.74 | KDR (1.00) | KDR | |
| SCHEMBL15400995 | 0.73 | TNNI3K (0.39) | KDRCCR6 | |
| SCHEMBL5889065 | 0.72 | KDR (1.00) | KDR | |
| SCHEMBL7235039 | 0.69 | KDR (0.62) | KDR | |
| SCHEMBL7237790 | 0.69 | KDR (0.64) | KDR | |
| SCHEMBL28944648 | 0.69 | KDR (0.72) | KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6586424-B2 | Anticancer agents; anticholesterol agents | MERCK & CO., INC. | 2003-07-01 | — | — | US | disclosed |
| US-6586423-B2 | 2-(Pyridin-2-ylamino)-thiazole-5-carbonitrile derivatives; angiogenesis inhibitors; antitumor and anticarcinogenic agents; atherosclerosis, macular degeneration, diabetic retinopathy | MERCK & CO., INC. | 2003-07-01 | — | — | US | disclosed |