Sugi Predict

Sugi Predict / Compounds / SCHEMBL723004

SCHEMBL723004

SCHEMBL723004

O=C(Nc1scc(-c2ccc(Br)cc2)c1C(=O)O)c1cccc(F)c1

nearest known ligand 0.77

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ CASP3 P42574 1/20 0.77
▸ SENP8 Q96LD8 1/20 0.77
▸ SENP7 Q9BQF6 1/20 0.77
▸ SENP6 Q9GZR1 1/20 0.77
▸ MEN1 O00255 5/20 0.65
▸ KMT2A Q03164 5/20 0.65
▸ RAB9A P51151 3/20 0.65
▸ NPC1 O15118 2/20 0.65
▸ NLRP3 Q96P20 1/20 0.63
▸ TNF P01375 1/20 0.61
▸ PRNP P04156 1/20 0.61
▸ NOD2 Q9HC29 1/20 0.61
▸ NOD1 Q9Y239 1/20 0.61
▸ ANO1 Q5XXA6 10/20 0.61
▸ ANO2 Q9NQ90 1/20 0.56
▸ TP53 P04637 1/20 0.54
▸ SMN1; SMN2 Q16637 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15233176 0.91 CASP3 (0.83) CASP3SENP8SENP7SENP6MEN1
SCHEMBL3629752 0.89 MEN1 (0.76) CASP3SENP8SENP7SENP6MEN1
SCHEMBL3630778 0.89 ANO1 (0.71) CASP3SENP8SENP7SENP6MEN1
SCHEMBL27815380 0.88 MEN1 (0.61) CASP3SENP8SENP7SENP6MEN1
SCHEMBL12314172 0.87 MEN1 (0.80) CASP3SENP8SENP7SENP6MEN1
SCHEMBL3630318 0.87 MEN1 (0.64) CASP3SENP8SENP7SENP6MEN1
SCHEMBL3628387 0.87 CASP3 (1.00) CASP3SENP8SENP7SENP6MEN1
SCHEMBL13926386 0.87 CASP3 (0.77) CASP3SENP8SENP7SENP6MEN1
SCHEMBL3629758 0.86 MEN1 (0.80) CASP3SENP8SENP7SENP6MEN1
SCHEMBL3626808 0.85 MEN1 (0.70) CASP3SENP8SENP7SENP6MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 106 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8263641-B2 Compounds that modulate intracellular calcium CALCIMEDICA, INC. (US) 2012-09-11 — — US claimed
CN-101854933-A Compounds that modulate intracellular calcium CALCIMEDICA INC 2010-10-06 — — CN claimed
EP-2200607-A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM Calcimedica, Inc. (US) 2010-06-30 — — EP claimed
US-20090137659-A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM CALCIMEDICA, INC. (US) 2009-05-28 — — US claimed
WO-2009035818-A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM CALCIMEDICA, INC. (US) 2009-03-19 — — WO claimed
US-11905248-B2 Compounds that modulate intracellular calcium CALCIMEDICA, INC. (US) 2024-02-20 — — US disclosed
CN-114591311-A Compounds that modulate intracellular calcium 钙医学公司 2022-06-07 — — CN disclosed
EP-2563759-B1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM CALCIMEDICA INC (US) 2022-04-06 — — EP disclosed
US-20200317617-A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM AVENUE CAPITAL MANAGEMENT II, L.P. 2020-10-08 — — US disclosed
US-10703722-B2 Compounds that modulate intracellular calcium CALCIMEDICA, INC. (US) 2020-07-07 — — US disclosed
US-10336738-B2 Compounds that modulate intracellular calcium CALCIMEDICA, INC. (US) 2019-07-02 — — US disclosed
US-10106529-B2 Compounds that modulate intracellular calcium CALCIMEDIA, INC. (US) 2018-10-23 — — US disclosed
WO-2010034003-A2 BENZYLTHIOTETRAZOLE INHIBITORS OF STORE OPERATED CALCIUM RELEASE CALCIMEDICA, INC. (US) 2010-03-25 — — WO disclosed
WO-2010027875-A2 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM CALCIMEDICA INC. (US) 2010-03-11 — — WO disclosed
US-20100056532-A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM CALCIMEDICA, INC. (US) 2010-03-04 — — US disclosed
WO-2010025295-A2 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM CALCIMEDICA INC. (US) 2010-03-04 — — WO disclosed
US-20090137659-A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM CALCIMEDICA, INC. (US) 2009-05-28 — — US disclosed
WO-2009035818-A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM CALCIMEDICA, INC. (US) 2009-03-19 — — WO disclosed
US-20080293092-A1 CALCIUM CHANNEL PROTEINS AND USES THEREOF CALCIMEDICA, INC. (US) 2008-11-27 — — US disclosed
US-20080293092-A1 CALCIUM CHANNEL PROTEINS AND USES THEREOF CALCIMEDICA, INC. (US) 2008-11-27 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10106529-B2 Compounds that modulate intracellular calcium ORAI1, SARAF, RYR2 CASP3 2232/4885SENP8 3756/4885SENP7 3940/4885
US-10703722-B2 Compounds that modulate intracellular calcium ORAI1, SARAF, RYR2 CASP3 2232/4885SENP8 3756/4885SENP7 3940/4885
US-20100056532-A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM ORAI1, SARAF, RYR2 CASP3 2232/4885SENP8 3756/4885SENP7 3940/4885
US-10336738-B2 Compounds that modulate intracellular calcium ORAI1, SARAF, RYR2 CASP3 2232/4885SENP8 3756/4885SENP7 3940/4885
US-20200317617-A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM ORAI1, SARAF, RYR2 CASP3 2232/4885SENP8 3756/4885SENP7 3940/4885
US-20090137659-A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM ORAI1, SARAF, RYR2 CASP3 2232/4885SENP8 3756/4885SENP7 3940/4885
US-11905248-B2 Compounds that modulate intracellular calcium ORAI1, SARAF, RYR2 CASP3 2232/4885SENP8 3756/4885SENP7 3940/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.