Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.63 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 4/20 | 0.53 |
| ▸ | MAOA | P21397 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | BCHE | P06276 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.51 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7229907 | 0.82 | MAOB (0.63) | ABCB1KMT2AMAPTMEN1POLB | |
| SCHEMBL7221186 | 0.82 | NPC1 (0.75) | ABCB1KMT2AMAPTMEN1POLB | |
| SCHEMBL7223900 | 0.81 | MAOB (0.61) | ABCB1KMT2AMAPTMEN1POLB | |
| SCHEMBL7222827 | 0.81 | MAOB (0.61) | ABCB1KMT2AMAPTMEN1POLB | |
| SCHEMBL7229383 | 0.78 | MAOB (0.59) | ABCB1KMT2AMAPTMEN1POLB | |
| SCHEMBL18083725 | 0.77 | KDR (0.59) | KMT2AMAPTMEN1POLBNPC1 | |
| SCHEMBL18083772 | 0.76 | SMN1; SMN2 (0.64) | KMT2AMAPTMEN1POLBNPC1 | |
| SCHEMBL18083681 | 0.75 | ACKR3 (0.54) | MAPTNPC1RAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL7220985 | 0.74 | MAOB (0.60) | ABCB1KMT2AMAPTMEN1POLB | |
| SCHEMBL7221811 | 0.74 | MAOA (0.63) | ABCB1KMT2AMAPTMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6552054-B1 | For prophylaxis and therapy of bone diseases and chondropathy | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-04-22 | — | — | US | disclosed |
| EP-1211251-A1 | CHROMONE DERIVATIVES, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2002-06-05 | — | — | EP | disclosed |