Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 9/20 | 0.40 |
| ▸ | HTR3A | P46098 | 6/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 5/20 | 0.39 |
| ▸ | HTR3B | O95264 | 5/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 5/20 | 0.39 |
| ▸ | HTR3C | Q8WXA8 | 5/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.36 |
| ▸ | STIM1 | Q13586 | 2/20 | 0.35 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESRRG | P62508 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7234714 | 0.84 | HSD17B10 (0.38) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL7230458 | 0.83 | NPC1 (0.38) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL7223422 | 0.83 | HPGD (0.38) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL374986 | 0.83 | CHRNA7 (0.60) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL7224345 | 0.83 | CHRNA7 (0.60) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL7223682 | 0.83 | AKT1 (0.40) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL7224193 | 0.82 | HDAC3 (0.53) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL7231855 | 0.82 | CHRNA7 (0.58) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL7225958 | 0.82 | KDM4E (0.39) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL7230597 | 0.82 | NPC1 (0.39) | CHRNA7HTR3AHTR3EHTR3BHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |