Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.38 |
| ▸ | HTR3B | O95264 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.38 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | SLC8A1 | P32418 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7222700 | 0.90 | SLC6A4 (0.37) | HDAC6CHRNA7F10ALDH1A1 | |
| SCHEMBL7226621 | 0.90 | SLC6A3 (0.39) | HDAC6CHRNA7 | |
| SCHEMBL7227027 | 0.85 | SLC6A3 (0.36) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7123390 | 0.84 | HDAC6 (0.38) | HDAC6HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7231479 | 0.82 | HDAC6 (0.37) | HDAC6HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7223713 | 0.82 | CHRNA7 (0.34) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7231965 | 0.82 | CHRNA7 (0.36) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7071274 | 0.82 | USP30 (0.53) | HDAC6HTR3EHTR3BHTR3AHTR3D | |
| Hydrochloric Acid SCHEMBL7075524 | 0.81 | USP30 (0.52) | HDAC6HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7116913 | 0.80 | HDAC6 (0.39) | HDAC6HTR3EHTR3BHTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |