Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 10/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | CASP3 | P42574 | 2/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.33 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2418262 | 0.80 | ITK (0.42) | ITKNPC1RAB9AAURKAAURKB | |
| SCHEMBL6629440 | 0.77 | RAB9A (0.50) | ITKNPC1RAB9AAURKAAURKB | |
| SCHEMBL7231262 | 0.69 | — | — | |
| SCHEMBL6469991 | 0.67 | AURKA (0.50) | ITKNPC1RAB9AAURKAAURKB | |
| SCHEMBL5264609 | 0.65 | RAB9A (0.46) | ITKNPC1RAB9AAURKAAURKB | |
| SCHEMBL1352369 | 0.63 | AURKA (0.49) | ITKNPC1RAB9AAURKAAURKB | |
| SCHEMBL12115291 | 0.63 | RAB9A (0.55) | ITKNPC1RAB9AAURKAAURKB | |
| SCHEMBL4179029 | 0.62 | KDM4E (0.58) | NPC1RAB9AAURKAAURKBKDM4E | |
| SCHEMBL6336392 | 0.62 | RAB9A (0.53) | ITKNPC1RAB9AAURKAAURKB | |
| SCHEMBL31555117 | 0.62 | RAB9A (0.53) | ITKNPC1RAB9AAURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6653321-B1 | Stimulating kinase activity of insulin receptor; type II diabetes; hyperglycemia | TELIK, INC. | 2003-11-25 | — | — | US | claimed |