Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9545277 | 0.83 | CYP1A2 (0.49) | CYP1A2TDP1GPR119ALDH1A1 | |
| SCHEMBL27872103 | 0.83 | CYP1A2 (0.49) | CYP1A2TDP1GPR119ALDH1A1 | |
| SCHEMBL5982884 | 0.83 | CYP1A2 (0.49) | CYP1A2TDP1GPR119ALDH1A1 | |
| SCHEMBL7797043 | 0.80 | CYP2C19 (0.43) | LMNACYP1A2CYP3A4CYP11B1CYP11B2 | |
| SCHEMBL7797112 | 0.80 | CYP2C19 (0.43) | LMNACYP1A2CYP3A4CYP11B1CYP11B2 | |
| SCHEMBL6979885 | 0.77 | CYP1A2 (0.54) | LMNACYP1A2CYP3A4CYP11B1CYP11B2 | |
| SCHEMBL6979883 | 0.77 | CYP1A2 (0.54) | LMNACYP1A2CYP3A4CYP11B1CYP11B2 | |
| SCHEMBL6037641 | 0.77 | CYP1A2 (0.54) | LMNACYP1A2CYP3A4CYP11B1CYP11B2 | |
| SCHEMBL4702232 | 0.76 | LMNA (0.67) | LMNACYP1A2CYP3A4CYP11B1CYP11B2 | |
| SCHEMBL10334929 | 0.76 | LMNA (0.44) | LMNACYP1A2CYP3A4CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6569847-B1 | Inhibitors of cathepsins for treating muscular dystrophy, osteoporosis, rheumatoid arthritis, neuronal or cardiac ischaemia, allergy, or Chagas disease | NAEJA PHARMACEUTICALS INC. (CA) | 2003-05-27 | — | — | US | disclosed |
| EP-1165506-A1 | SUBSTITUTED AZETIDIN-2-ONES AS CYSTEINE PROTEASE INHIBITORS | Naeja Pharmaceutical Inc. (CA) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059881-A1 | SUBSTITUTED AZETIDIN-2-ONES AS CYSTEINE PROTEASE INHIBITORS | NAEJA PHARMACEUTICAL INC (CA) | 2000-10-12 | — | — | WO | disclosed |