Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 15/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | PPARA | Q07869 | 1/20 | 0.50 |
| ▸ | LDHA | P00338 | 1/20 | 0.49 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6528925 | 0.92 | TPH1 (0.69) | TPH1PPARGLDHA | |
| SCHEMBL2000541 | 0.85 | PPARG (0.55) | TPH1PPARGPPARALDHA | |
| SCHEMBL30040624 | 0.84 | TPH1 (0.54) | TPH1PPARGPPARALDHA | |
| SCHEMBL2000467 | 0.84 | TPH1 (0.54) | TPH1PPARGPPARALDHA | |
| SCHEMBL429637 | 0.84 | TPH1 (0.54) | TPH1PPARGPPARALDHA | |
| SCHEMBL6168594 | 0.83 | TPH1 (0.68) | TPH1PPARGPPARALDHA | |
| SCHEMBL5213839 | 0.83 | PPARG (0.63) | TPH1PPARGPPARA | |
| SCHEMBL7227938 | 0.83 | PPARG (0.63) | TPH1PPARGPPARA | |
| SCHEMBL31398354 | 0.83 | PPARG (0.63) | TPH1PPARGPPARA | |
| SCHEMBL29810055 | 0.82 | TPH1 (1.00) | TPH1ALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6645939-B1 | Very late antigen-4 (VLA) integrin antagonists; antiallergens, antiasthmatics, and antiinflammatory agents; multiple sclerosis, autoimmune disease treatment | MERCK & CO., INC. | 2003-11-11 | — | — | US | disclosed |