Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | SUV39H2 | Q9H5I1 | 12/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 2/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4253922 | 0.89 | SUV39H2 (0.45) | SUV39H2DRD2CTSKPIM1PIM3 | |
| SCHEMBL15093029 | 0.89 | SUV39H2 (0.46) | SUV39H2DRD2CTSKPIM1PIM3 | |
| SCHEMBL2578938 | 0.89 | SUV39H2 (0.46) | SUV39H2DRD2CTSKPIM1PIM3 | |
| SCHEMBL4253928 | 0.89 | SUV39H2 (0.45) | SUV39H2DRD2CTSKPIM1PIM3 | |
| SCHEMBL3384005 | 0.89 | MAPT (0.48) | SUV39H2LMNADRD2CTSKPIM1 | |
| SCHEMBL31331790 | 0.87 | DRD2 (0.45) | SUV39H2LMNADRD2CTSKPIM1 | |
| SCHEMBL31331951 | 0.87 | DRD2 (0.45) | SUV39H2LMNADRD2CTSKPIM1 | |
| SCHEMBL5385948 | 0.85 | HPGD (0.54) | HPGDSUV39H2LMNAALDH1A1MAPT | |
| SCHEMBL31331695 | 0.84 | SUV39H2 (0.43) | SUV39H2DRD2CTSKPIM1PIM3 | |
| SCHEMBL31331762 | 0.84 | SUV39H2 (0.43) | SUV39H2DRD2CTSKPIM1PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6555541-B1 | P2X7 receptor antagonists for treatment of inflammatory respiratory system disorders such as asthma; for example, 2-(3,4-Difluorophenylamino)-N-(2-methyl-5-piperazin-1-yl-methyl-phenyl) -acetamide, trihydrochloride | ASTRAZENECA UK LIMITED (GB) | 2003-04-29 | — | — | US | disclosed |
| US-6492355-B1 | Adamantane derivatives | ASTRAZENECA AB (SE) | 2002-12-10 | — | — | US | disclosed |
| EP-1185522-A1 | SUBSTITUTED PHENYL COMPOUNDS WITH IMMUNOSUPPRESSING ACTIVITY AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | AstraZeneca AB (SE) | 2002-03-13 | — | — | EP | disclosed |
| WO-2000071529-A1 | SUBSTITUTED PHENYL COMPOUNDS WITH IMMUNOSUPPRESSING ACTIVITY AND PHARMACEUTICAL COMPOSITIONS | ASTRAZENECA AB (SE) | 2000-11-30 | — | — | WO | disclosed |