Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 7/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 9/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 9/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ITGAV | P06756 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | TPH1 | P17752 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7235902 | 0.94 | GRM2 (0.41) | GRM2ITGB3ITGA2BMAPK1L3MBTL1 | |
| SCHEMBL7235382 | 0.92 | GRM2 (0.38) | GRM2ITGB3ITGA2BMAPK1L3MBTL1 | |
| SCHEMBL7229606 | 0.90 | GRM2 (0.42) | GRM2ITGB3ITGA2BMAPK1L3MBTL1 | |
| SCHEMBL7236454 | 0.88 | GRM2 (0.40) | GRM2ITGB3ITGA2BMAPK1L3MBTL1 | |
| SCHEMBL7229898 | 0.86 | GRM2 (0.38) | GRM2ITGB3ITGA2BMAPK1L3MBTL1 | |
| SCHEMBL7228296 | 0.84 | GRM2 (0.41) | GRM2ITGB3ITGA2BMAPK1L3MBTL1 | |
| SCHEMBL7238081 | 0.82 | GRM2 (0.41) | GRM2ITGB3ITGA2BMAPK1L3MBTL1 | |
| SCHEMBL7235814 | 0.82 | GRM2 (0.41) | GRM2ITGB3ITGA2BMAPK1L3MBTL1 | |
| SCHEMBL7228295 | 0.82 | ITGB3 (0.41) | GRM2ITGB3ITGA2BMAPK1L3MBTL1 | |
| SCHEMBL7228961 | 0.81 | GRM2 (0.39) | GRM2ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6602876-B1 | Adhesion receptor antagonists | MERCK PATENT GMBH (DE) | 2003-08-05 | — | — | US | disclosed |
| US-6204280-B1 | OXAZOLIDINONE DERIVATIVE, ANTICOAGULANT | MERCK PATENT GESELLSCHAFT MIT BERSCHRANKTER HAFTUNG (DE) | 2001-03-20 | — | — | US | disclosed |
| EP-0710657-B1 | Antagonists of adhesion receptors | MERCK PATENT GMBH (DE) | 1998-08-26 | — | — | EP | disclosed |
| EP-0710657-A1 | Antagonists of adhesion receptors | MERCK PATENT GmbH (DE) | 1996-05-08 | — | — | EP | disclosed |