Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.66 |
| ▸ | ERBB2 | P04626 | 14/20 | 0.66 |
| ▸ | ERBB4 | Q15303 | 8/20 | 0.58 |
| ▸ | JAK3 | P52333 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4187462 | 0.88 | EGFR (0.75) | EGFRERBB2ERBB4JAK3MEN1 | |
| SCHEMBL7240611 | 0.83 | EGFR (0.54) | EGFRERBB2ERBB4JAK3 | |
| SCHEMBL7235412 | 0.81 | EGFR (0.63) | EGFRERBB2ERBB4JAK3 | |
| SCHEMBL4194568 | 0.80 | EGFR (1.00) | EGFRERBB2 | |
| SCHEMBL7238660 | 0.79 | EGFR (0.75) | EGFRERBB2ERBB4JAK3 | |
| SCHEMBL7126674 | 0.79 | EGFR (0.70) | EGFRERBB2ERBB4JAK3 | |
| SCHEMBL4201064 | 0.78 | EGFR (0.72) | EGFRERBB2ERBB4 | |
| SCHEMBL7221059 | 0.78 | EGFR (0.62) | EGFRERBB2ERBB4JAK3 | |
| SCHEMBL7240784 | 0.78 | EGFR (0.70) | EGFRERBB2ERBB4JAK3 | |
| SCHEMBL7219974 | 0.77 | EGFR (0.61) | EGFRERBB2ERBB4JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562818-B1 | For treating cancer, atherosclerosis, restenosis, endometriosis, and psoriasis | WARNER-LAMBERT COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562818-B1 | For treating cancer, atherosclerosis, restenosis, endometriosis, and psoriasis | WARNER-LAMBERT COMPANY | 2003-05-13 | — | — | US | disclosed |
| US-6127374-A | AN ENZYME INHIBITOR FOR TREATING CANCER, RESTENOSIS, ATHEROSCLEROSIS, ENDOMETRIOSIS AND PSORIASIS | WARNER-LAMBERT COMPANY (US) | 2000-10-03 | — | — | US | disclosed |
| WO-1999006378-A1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | disclosed |