Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 5/20 | 0.53 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.53 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.53 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.53 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.53 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.53 |
| ▸ | GSAP | A4D1B5 | 1/20 | 0.53 |
| ▸ | CCKBR | P32239 | 12/20 | 0.52 |
| ▸ | SPPL2A | Q8TCT8 | 1/20 | 0.47 |
| ▸ | CCKAR | P32238 | 8/20 | 0.46 |
| ▸ | NOTCH1 | P46531 | 1/20 | 0.46 |
| ▸ | NOTCH3 | Q9UM47 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7536076 | 0.88 | CCKBR (0.51) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4994804 | 0.88 | CCKBR (0.51) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4411861 | 0.88 | CCKBR (0.57) | CCKBRCCKAR | |
| SCHEMBL4423494 | 0.87 | CCKBR (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7228006 | 0.87 | CCKBR (0.55) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4415245 | 0.85 | CCKBR (0.56) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4414894 | 0.84 | CCKBR (0.53) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4414822 | 0.84 | PSEN1 (0.58) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4995861 | 0.82 | PSEN1 (0.66) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4413108 | 0.81 | PSEN1 (0.65) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6667305-B1 | Alzheimer's disease; beta-amyloid peptide is a small fragment of the amyloid precursor protein | ATHENA NEUROSCIENCES, INC. | 2003-12-23 | — | — | US | disclosed |
| US-6635632-B1 | Alzheimer's disease | ATHENA NEUROSCIENCES, INC. | 2003-10-21 | — | — | US | disclosed |