⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15947436 | 0.97 | KDM4E (0.39) | — | |
| SCHEMBL14227863 | 0.97 | KDM4E (0.39) | — | |
| SCHEMBL15947442 | 0.97 | KDM4E (0.39) | — | |
| SCHEMBL17193180 | 0.93 | — | — | |
| SCHEMBL9795604 | 0.74 | — | — | |
| SCHEMBL689737 | 0.73 | — | — | |
| SCHEMBL541379 | 0.73 | — | — | |
| SCHEMBL899987 | 0.70 | TSHR (0.39) | — | |
| SCHEMBL12514471 | 0.70 | NOS3 (0.40) | — | |
| SCHEMBL3676789 | 0.70 | NOS3 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220184185-A1 | MRNA BASED ENZYME REPLACEMENT THERAPY COMBINED WITH A PHARMACOLOGICAL CHAPERONE FOR THE TREATMENT OF LYSOSOMAL STORAGE DISORDERS | MODERNATX, INC. | 2022-06-16 | — | — | US | disclosed |
| EP-3215509-B1 | SUBSTITUTED PYRROLO[1,2-A]PYRIMIDINES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS | LYSOSOMAL THERAPEUTICS INC (US) | 2020-02-26 | — | — | EP | disclosed |
| WO-2020023390-A1 | MRNA BASED ENZYME REPLACEMENT THERAPY COMBINED WITH A PHARMACOLOGICAL CHAPERONE FOR THE TREATMENT OF LYSOSOMAL STORAGE DISORDERS | MODERNATX, INC. (US) | 2020-01-30 | — | — | WO | disclosed |
| EP-2785335-B1 | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF DARIER DISEASE | INST NAT DE LA SANTÉ ET DE LA RECH MÉDICALE (INSERM) (FR) | 2017-06-14 | — | — | EP | disclosed |
| US-20150202185-A1 | COMPOSITIONS AND METHODS FOR TREATING LYSOSOMAL DISORDERS | TAIJI BIOMEDICAL, INC. | 2015-07-23 | — | — | US | disclosed |
| US-9023845-B2 | Compositions and methods for treating lysosomal disorders | NEURALTUS PHARMACEUTICALS, INC. (US) | 2015-05-05 | — | — | US | disclosed |
| US-20150044193-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF ALTERED a-SYNUCLEIN FUNCTION | NEURALTUS PHARMACEUTICALS, INC. | 2015-02-12 | — | — | US | disclosed |
| US-20140350049-A1 | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF DARIER DISEASE | UNIVERSITE PARIS DESCARTES (FR) | 2014-11-27 | — | — | US | disclosed |
| EP-2785335-A1 | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF DARIER DISEASE | Institut National de la Sante et de la Recherche Medicale (INSERM) (FR) | 2014-10-08 | — | — | EP | disclosed |
| EP-2139323-B1 | TREATMENT OF GAUCHER DISEASE WITH SPECIFIC PHARMACOLOGICAL CHAPERONES AND MONITORING TREATMENT USING SURROGATE MARKERS | AMICUS THERAPEUTICS INC (US) | 2013-08-21 | — | — | EP | disclosed |
| EP-1682504-A2 | HYDROXY PIPERIDINE DERIVATIVES TO TREAT GAUCHER DISEASE | Amicus Therapeutics Inc. (US) | 2006-07-26 | — | — | EP | disclosed |
| EP-1682134-A2 | GLUCOIMIDAZOLE AND POLYHYDROXYCYCLOHEXENYL AMINE DERIVATIVES TO TREAT GAUCHER DISEASE | Amicus Therapeutics Inc. (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005046611-A3 | GLUCOIMIDAZOLE AND POLYHYDROXYCYCLOHEXENYL AMINE DERIVATIVES TO TREAT GAUCHER DISEASE | AMICUS THERAPEUTICS INC (US) | 2005-09-09 | — | — | WO | disclosed |
| US-20050137223-A1 | Glucoimidazole and polyhydroxycyclohexenyl amine derivatives to treat gaucher disease | AMICUS THERAPEUTICS, INC. | 2005-06-23 | — | — | US | disclosed |
| US-20050137223-A1 | Glucoimidazole and polyhydroxycyclohexenyl amine derivatives to treat gaucher disease | AMICUS THERAPEUTICS, INC. | 2005-06-23 | — | — | US | disclosed |
| US-20050137223-A1 | Glucoimidazole and polyhydroxycyclohexenyl amine derivatives to treat gaucher disease | AMICUS THERAPEUTICS, INC. | 2005-06-23 | — | — | US | disclosed |
| US-20050130972-A1 | Hydroxy piperidine derivatives to treat gaucher disease | AMICUS THERAPEUTICS, INC. | 2005-06-16 | — | — | US | disclosed |
| WO-2005046612-A2 | HYDROXY PIPERIDINE DERIVATIVES TO TREAT GAUCHER DISEASE | AMICUS THERAPEUTICS INC. (US) | 2005-05-26 | — | — | WO | disclosed |
| WO-2005046611-A2 | GLUCOIMIDAZOLE AND POLYHYDROXYCYCLOHEXENYL AMINE DERIVATIVES TO TREAT GAUCHER DISEASE | AMICUS THERAPEUTICS INC. (US) | 2005-05-26 | — | — | WO | disclosed |
| WO-2005046611-A2 | GLUCOIMIDAZOLE AND POLYHYDROXYCYCLOHEXENYL AMINE DERIVATIVES TO TREAT GAUCHER DISEASE | AMICUS THERAPEUTICS INC. (US) | 2005-05-26 | — | — | WO | disclosed |